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05-822 | Anti-Rho (-A, -B, -C) Antibody, clone 3L74, rabbit monoclonal

100 µL  
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      Replacement Information

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      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, R WB Rb Purified Monoclonal Antibody
      Catalogue Number05-822
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-Rho (-A, -B, -C) Antibody, clone 3L74, rabbit monoclonal
      Product Information
      ApplicationAnti-Rho (-A Antibody, -B, -C), clone 3L74 is an antibody against Rho (-A, -B, -C) for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated, synthetic peptide (SYPDTDVILMCFSIDSPDSLENKK) corresponding to amino acids 73-94 of human Rho (-A, -B, -C), with two terminal lysines added to increase peptide solubility
      Cloneclone 3L74
      SpecificityRecognizes Rho (-A, -B, -C)
      Species Reactivity
      • Human
      • Rat
      Species Reactivity NoteBroad species cross-reactivity expected based on sequence homology
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • RHOA
      • RHO12
      • Rho12
      • RhoA
      • RHOH12
      • H12
      • ARHA
      • ARH12
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P61586 # Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. May be an activator of PLCE1.
      COFACTOR: Magnesium.
      SIZE: 193 amino acids; 21768 Da
      SUBUNIT: Binds PRKCL1, ROCK1 and ROCK2. Interacts with ARHGEF3, NET1 and RTKN. Interacts with PLCE1 and AKAP13.
      SUBCELLULAR LOCATION: Membrane; Lipid-anchor.
      DOMAIN: SwissProt: P61586 The basic-rich region is essential for yopT recognition and cleavage.
      PTM: Substrate for botulinum ADP-ribosyltransferase. & Cleaved by yopT protease when the cell is infected by some Yersinia pathogens. This removes the lipid attachment, and leads to its displacement from plasma membrane and to subsequent cytoskeleton cleavage.
      SIMILARITY: Belongs to the small GTPase superfamily. Rho family.
      Molecular WeightMr 22kDa
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on modified RIPA lysates from HL-60 cells
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 2 years at -20°C from date of shipment
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information


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      Certificados de análisis

      CargoNúmero de lote
      Anti-Rho (-A, -B, -C), clone 3L74 (rabbit monoclonal IgG) - JBC1381959 JBC1381959
      Anti-Rho (-A, -B, -C), clone 3L74 (rabbit monoclonal IgG)_2826975 2826975
      Anti-Rho (-A, -B, -C), clone 3L74 - 2532233 2532233
      Anti-Rho (-A, -B, -C), clone 3L74 - 27111 27111
      Anti-Rho (-A, -B, -C), clone 3L74 - 32510 32510
      Anti-Rho (-A, -B, -C), clone 3L74 -2720344 2720344

      Referencias bibliográficas

      Visión general referenciasPub Med ID
      Xenopus Kazrin interacts with ARVCF-catenin, spectrin and p190B RhoGAP, and modulates RhoA activity and epithelial integrity.
      Cho, K; Vaught, TG; Ji, H; Gu, D; Papasakelariou-Yared, C; Horstmann, N; Jennings, JM; Lee, M; Sevilla, LM; Kloc, M; Reynolds, AB; Watt, FM; Brennan, RG; Kowalczyk, AP; McCrea, PD
      Journal of cell science 123 4128-44 2010

      Mostrar resumen
      21062899 21062899
      Prognostic value of rho GTPases and rho guanine nucleotide dissociation inhibitors in human breast cancers.
      Jiang, Wen G, et al.
      Clin. Cancer Res., 9: 6432-40 (2003) 2003

      Mostrar resumen
      14695145 14695145
      The PRK2 kinase is a potential effector target of both Rho and Rac GTPases and regulates actin cytoskeletal organization.
      Vincent, S and Settleman, J
      Mol. Cell. Biol., 17: 2247-56 (1997) 1997

      Mostrar resumen
      9121475 9121475
      Signal-transducing protein phosphorylation cascades mediated by Ras/Rho proteins in the mammalian cell: the potential for multiplex signalling.
      Denhardt, D T
      Biochem. J., 318 ( Pt 3): 729-47 (1996) 1996

      Mostrar resumen
      8836113 8836113