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04-002 | Anti-SOCS1 Antibody, clone 4H1

04-002
100 µg  
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      Descripción

      Replacement Information

      Ofertas especiales

      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M IP, WB M Purified Monoclonal Antibody
      Description
      Catalogue Number04-002
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-SOCS1 Antibody, clone 4H1
      Alternate Names
      • suppressor of cytokine signaling 1
      • CIS1
      • CISH1
      • JAB
      • SOCS-1
      • SSI-1
      • SSI1
      • TIP3
      References
      Product Information
      FormatPurified
      Applications
      ApplicationAnti-SOCS1 Antibody, clone 4H1 is an antibody against SOCS1 for use in IP & WB.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Application NotesImmunoblot Analysis: 1:1,000 dilution of this antibody detected SOCS1 in KG-1 cell lysate.
      Immunoprecipitation (IP): 10 μg of this antibody immunoprecipitated SOCS1 from 200 μL of cell extract in RIPA buffer.
      Biological Information
      Immunogenmouse SOCS1 recombinant GST fusion protein encompassing amino acids 2-78.
      Clone4H1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityRecognizes SOCS1
      IsotypeIgG1
      Species Reactivity
      • Human
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.
      Gene Symbol
      • SOCS1
      • SSI-1
      • Cish1
      • TIP-3
      • TIP3
      • CISH1
      • SSI1
      • CIS1
      • SOCS-1
      • JAB
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: O15524 # SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT3 pathway. Through binding to JAKs, inhibits their kinase activity. In vitro, also suppresses Tec protein- tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival (By similarity). Probable substrate-recognition component of a SCF- like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2.
      SIZE: 211 amino acids; 23551 Da
      SUBUNIT: Interacts with multiple activated signaling proteins of the tyrosine kinase signaling pathway including JAK family kinases, TEC, KIT, GRB2 and VAV. Binding to JAKs is mediated through the KIR and SH2 domains to a phosphorylated tyrosine residue within the JAK JH1 domain. Binds the SH3 domain of GRB2 via diproline determinants in the N-terminus, and the N-terminal regulatory domain of VAV (By similarity). Interacts with the Elongin BC complex (TCEB1 and TCEB2). Component of an ECS CBC(VHL) E3 ubiquitin ligase complex which contains Elongin BC complex, CUL5, RBX1 and SOCS1 (By similarity). Interacts with TRIM8 (By similarity). Interacts with CUL2.
      TISSUE SPECIFICITY: Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes.
      DOMAIN: SwissProt: O15524 The ESS and SH2 domains are required for JAK phosphotyrosine binding. Further interaction with the KIR domain is necessary for signal and kinase inhibition. & The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes. The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV] and is part of the SOCS box (By similarity).
      SIMILARITY: Contains 1 SH2 domain. & Contains 1 SOCS box domain.
      Molecular Weight37 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by immunoblot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions2 years at 2° to 8°C from date of shipment.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Certificados de análisis

      CargoNúmero de lote
      Anti-SOCS1, clone 4H1 (Suppressor of Cytokine Signaling 1) (Protein A purified mouse monoclonal) - 2462827 2462827
      Anti-SOCS1, clone 4H1 (Suppressor of Cytokine Signaling 1) (Protein A purified mouse monoclonal) - 2360561 2360561
      Anti-SOCS1, clone 4H1 (Suppressor of Cytokine Signaling 1) (Protein A purified mouse monoclonal) - DAM1828771 DAM1828771
      Anti-SOCS1, clone 4H1 - 2502954 2502954
      Anti-SOCS1, clone 4H1 - DAM1487538 DAM1487538
      Anti-SOCS1, clone 4H1 - DAM1567212 DAM1567212
      Anti-SOCS1, clone 4H1 - DAM1594190 DAM1594190
      Anti-SOCS1, clone 4H1 - DAM1636058 DAM1636058
      Anti-SOCS1, clone 4H1 - DAM1687493 DAM1687493
      Anti-SOCS1, clone 4H1 - DAM1770248 DAM1770248
      Anti-SOCS1, clone 4H1 -2694455 2694455
      Anti-SOCS1, clone 4H1 -2746278 2746278
      Anti-SOCS1, clone 4H1 -2802573 2802573
      anti-SOCS1, clone 4H1 - 0609041362 0609041362
      anti-SOCS1, clone 4H1 - JBC1364013 JBC1364013

      Referencias bibliográficas

      Visión general referenciasPub Med ID
      SOCS1 inhibits tumor necrosis factor-induced activation of ASK1-JNK inflammatory signaling by mediating ASK1 degradation.
      He, Yun, et al.
      J. Biol. Chem., 281: 5559-66 (2006) 2006

      Mostrar resumen
      16407264 16407264
      Suppressors of cytokine signaling (SOCS) 1 and SOCS3 interact with and modulate fibroblast growth factor receptor signaling
      Ben-Zvi, Tal, et al
      J Cell Sci, 119:380-7 (2006) 2006

      16410555 16410555
      SOCS1 [corrected] inhibits HPV-E7-mediated transformation by inducing degradation of E7 protein.
      Kamio, Masaki, et al.
      Oncogene, 23: 3107-15 (2004) 2004

      Mostrar resumen
      15021916 15021916