pDADMAC is a cationic polymer that is widely used as a flocculant in waste water treatment. We have developed a high-quality production and purification process suitable for use in GMP biotherapeutic manufacturing.
When used in a concentration between 0.01 and 0.05%, the pDADMAC polymer rapidly flocculates the negatively charged cells and cellular debris into larger particles via an ionic interaction mechanism.
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pDADMAC Flocculation Polymer
Clarification Made Easy
The current evolution to high cell density and high product titer cell cultures is placing a larger burden on traditional downstream clarification and purification operations. With high solid content and an increased number of submicron particles, separation techniques to remove all solids can be complex. To alleviate these bottlenecks, various types of pre-treatment are being employed to make the clarification process more efficient.
Polycationic polymer modified poly (diallyldimethyl-ammonium chloride) [pDADMAC] is a very effective flocculation polymer that can be used as a pre-treatment solution when used in combination with our Clarisolve® depth filters.It can reduce the area required for depth filtration by at least a factor 2-3x. This results in consumable, water flushing, and manufacturing footprint savings, thereby providing an alternative to centrifugation.
pDADMAC Flocculation Polymers
Learn more about Clarisolve® depth filters for efficient primary clarification of pre-treated feed streams.
Related Documents [PDF]
- Clarification Solutions for Pre-treated Feed Streams
- Clarification of Mammalian Cell Cultures by Depth Filtration
- Millistak+® and Clarisolve® Depth Filters at a Glance
- Evolving Clarification Strategies to Meet New Challenges
- Clarification Portfolio Guide
- Industrial Application of Impurity Flocculation to Streamline Antibody Purification Processes
