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SCT052 BioTracker Far-Red Peroxynitrite Live Cell Dye

Live cell imaging probe for detection and imaging peroxynitrite, a highly cytotoxic reactive nitrogen species (RNS).

SCT052
1 mg  
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      Descripción

      Replacement Information
      Description
      Catalogue NumberSCT052
      DescriptionBioTracker Far-Red Peroxynitrite Live Cell Dye
      OverviewReactive oxygen species (ROS) and nitrogen species (RNS) are implicated in various physiological and pathological processes. Among ROS and RNS, peroxynitrite (ONOO−) has attracted much special attention because of the key roles that it plays in signal transduction and antimicrobial activities. Peroxynitrite is endogenously produced by reaction of nitric oxide (NO) and superoxide radical anion (O2), however, ONOO− is more cytotoxic than NO or O2 alone, contributing to numerous pathologies such as cardiovascular disease and injury, diabetes, and cancer.

      The BioTracker Far-Red Peroxynitrite live cell dye can be used for ONOO- detection. This probe is cell permeable and displays a high sensitivity and selectivity towards peroxynitrite over other ROS/RNS.
      This probe can be used to detect exogenous and endogenous peroxynitrite in living systems and displays long wavelength absorption (600 nm) and emission (638 nm) bands.

      Spectral Properties
      Absorption: 600 nm
      Emissions: 638 nm

      References
      Wu D et al. A Far-Red-Emitting Fluorescence Probe for Sensitive and Selective Detection of Peroxynitrite in Live Cells and Tissues. Anal Chem. 2017, 89, 10924-10931.
      Alternate Names
      • Live cell imaging probe
      References
      Product Information
      Detection methodFluorescence
      PresentationLyophilized
      Applications
      ApplicationLive cell imaging probe for detection and imaging peroxynitrite, a highly cytotoxic reactive nitrogen species (RNS).
      Key Applications
      • Cell Based Assays
      Application NotesLive cell fluorescent imaging
      Biological Information
      Molecular Weight480.60 g/mol
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssurancePurity: ≥ 98% confirmed by HNMR, LC-MS and HPLC and elemental analysis
      Molar Mass: 480.60 g/mol
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore BioTracker Far red Peroxynitrite Live Cell Dye at -20°C, desiccate and protect from light
      Note: Centrifuge vial briefly to collect contents at bottom of vial before opening.
      Packaging Information
      Material Size1 mg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      SCT052 04054839008399