Millipore Sigma Vibrant Logo

Read All About It!

Stay up to date in analytical chromatography with Merck. Our brochures and guides offer valuable information about techniques and products that can support and optimize your investigations. Simply download your preferred literature from the list below, and remember to check back regularly for new publications.

HPLC Troubleshooting Guide

Untangle Your Liquid Chromatography Problems
HPLC Troubleshooting Guide
HPLC Troubleshooting Guide Our new, easy to use HPLC Troubleshooting Guide is organized into chapters covering the most common problems encountered in liquid chromatography.
  • Retention
  • Equilibration
  • Peaks
  • Recovery
  • Leaks
  • Selectivity
  • Baseline
  • Pressure

Order Your FREE Copy Here

Overview Catalog

The world of chromatography in your hands
  • In depth information covering Merck's chromatography products
  • Information about water purification systems and sample preparation
  • Method development support and applications, particulary for meeting pharmacopoeia requirements
  • Column selection guide and troubleshooting advice

More Information 
Order a Printed Copy

TLC/HPTLC Brochure

Fast and Precise
Thin Layer Chromatography by Merck

Technique: Thin Layer Chromatography
Product(s): TLC and HPTLC product range

  • Complete portfolio of TLC, HPTLC, and PLC plates
  • Fast, inexpensive method for qualitative and quantitative analysis
  • Simultaneous analysis of several samples under identical conditions

View & Download

Analytical HPLC and UHPLC Brochures


Do you need trouble-free speed?
The new Chromolith® HR

Technique: Analytical HPLC
Product(s): Chromolith® HighResolution HPLC Columns

  • Fast separations with easy method transfer
  • Column performance corresponds to 3 µm particle packed column, and is at least 50% higher than standard Chromolith® columns
  • Back pressure around 2 times lower than particle packed columns
  • 30% longer column lifetime compared to particle packed columns

View & Download

UHPLC² It's your choice!

Technique: Analytical HPLC
Product(s): Chromolith® and Purospher® STAR UHPLC columns

  • Chromolith® Fast Gradient HPLC columns: Fast and robust analysis at low pressure for reliable results even with difficult samples
  • Purospher® STAR RP-18 endcapped UHPLC columns: Excellent peak symmetry, performance and pH stability for highest flexibility and reliability in QC

View & Download


You can count on us!

Technique: Analytical HPLC
Product(s): LiChrospher® RP-select B

  • High reliability of HPLC results
  • Excellent batch-to-batch reproducibility
  • Master batch concept eliminates variations between different batches

View & Download


Purospher® STAR HPLC and UHPLC column
Outstanding performance  
Merck:/Freestyle/LE-Lab-Essentials/Chromatography/Brochures/LE-Purospher Broschure MM-200x266-02122014.jpg

Technique: Analytical HPLC
Product(s): Purospher® STAR and UHPLC columns®

  • Best in class RP-18e column for excellent peak symmetry, performance and pH stability
  • Less hydrophobic compounds, faster retention of very hydrophobic compounds
  • Enhanced selectivity for separation of aromatic compounds due to π-π interactions
  • Separation of carbohydrates and polar compounds with normal-phase or HILIC chromatography
  • Separation of polar compounds with normal-phase or HILIC (Si) chromatography
  • Ultra fast for UHPLC and excellent for LC-MS

View & Download

Purospher® STAR RP-18 endcapped UPLC columns
Speed meets performance!

Technique: Analytical HPLC
Product(s): Purospher® STAR RP-18 endcapped UPLC columns

  • Time and cost-saving solution
  • Ultra fast HPLC speeds up separation as much as 10 times, and dramatically cuts solvent consumption
  • Best peak symmetry, high pressure stability, and excellent pH stability

View & Download

SeQuant® CARS™ and SAMS™

SeQuant® CARS™ and SAMS™
Everything runs smoothly…

Technique: Analytical HPLC
Product(s): SeQuant® CARS™ and SAMS™

  • SeQuant® CARS™: Robust suppression system for high ionic strength eluents and gradient applications
  • SeQuant® SAMS™: High-capacity membrane suppressor for enhanced detection in ion chromatography

Order a free copy

SeQuant® ZIC® -HILIC

A practical guide to HILIC

Technique: Analytical HPLC
Product(s): SeQuant® ZIC® -HILIC HPLC columns

  • Everything needed to get started with HILIC (hydrophilic interaction liquid chromatography)
  • Tips for successful method development and troubleshooting
  • Example applications using SeQuant® ZIC®-HILIC and ZIC®-pHILIC HPLC columns

Order your free copy

For all who expect more

Technique: Analytical HPLC
Product(s): SeQuant® ZIC® -HILIC HPLC columns

  • High-performance, advanced hydrophilic interaction liquid chromatography
  • SeQuant® ZIC® -HILIC for the separation of all polar and hydrophilic compounds
  • SeQuant® ZIC®-pHILIC for challenging separations of polar and hydrophilic compounds

View & Download

It's hot!
SeQuant® ZIC® -cHILIC

Technique: Analytical HPLC
Product(s): SeQuant® ZIC® -cHILIC HPLC columns

  • High-performance HILIC columns with complementary selectivity for HPLC separation of polar hydrophilic compounds
  • Maximum LC-MS compatibility with minimized column bleed, excellent reproducibility and robustness

View & Download

Colecciones de aplicaciones de la HPLC

Colecciones de aplicaciones de la HPLC

Notas de aplicación y métodos

Más información