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565761 γ-Secretase Inhibitor IV - Calbiochem

The γ-Secretase Inhibitor IV controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

γ-Secretase Inhibitor IV - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: 2-Naphthoyl-VF-CHO, N-(2-Naphthoyl)-Val-phenylalaninal

Primary Target: Aβx-40
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565761
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Descripción

Replacement Information

Tabla espec. clave

Empirical Formula
C₂₅H₂₆N₂O₃

Precios y disponibilidad

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565761-1MG
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      Description
      OverviewA cell-permeable, reversible inhibitor of γ-secretase. Equipotently inhibits the release of Aβx-40 (ED50 = 2.6 µM) and Aβx-42 (ED50 = 2.7 µM) in HEK293 cells stably transfected with the Amyloid Precursor Protein Swedish mutants.
      Catalogue Number565761
      Brand Family Calbiochem®
      Synonyms2-Naphthoyl-VF-CHO, N-(2-Naphthoyl)-Val-phenylalaninal
      References
      ReferencesGreen, K.N., et al. 2002. J. Physiol. 541.3, 1013.
      Sinha, S. and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049.
      Product Information
      ATP CompetitiveN
      FormWhite lyophilized solid
      Hill FormulaC₂₅H₂₆N₂O₃
      Chemical formulaC₂₅H₂₆N₂O₃
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetAβx-40
      Primary Target IC<sub>50</sub>ED50 = 2.6 µM for Aβx-40
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide Sequence2-Naphthoyl-Val-Phe-CHO
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      565761-1MG 04055977267716

      Documentation

      γ-Secretase Inhibitor IV - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      γ-Secretase Inhibitor IV - Calbiochem Certificados de análisis

      CargoNúmero de lote
      565761

      Referencias bibliográficas

      Visión general referencias
      Green, K.N., et al. 2002. J. Physiol. 541.3, 1013.
      Sinha, S. and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-September-2008 RFH
      Synonyms2-Naphthoyl-VF-CHO, N-(2-Naphthoyl)-Val-phenylalaninal
      DescriptionA cell-permeable, reversible inhibitor of γ-secretase. Inhibits the release of Aβx-40 (ED50 = 2.6 µM) and Aβx-42 (ED50 = 2.7 µM) in HEK293 cells stably transfected with Amyloid Precursor Protein Swedish mutants.
      FormWhite lyophilized solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₅H₂₆N₂O₃
      Peptide Sequence2-Naphthoyl-Val-Phe-CHO
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesGreen, K.N., et al. 2002. J. Physiol. 541.3, 1013.
      Sinha, S. and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049.