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MABC975 Anti-Arylsulfatase B Antibody, clone 10G6.1

Anti-Arylsulfatase B Antibody, clone 10G6.1 : Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Research Category: Apoptosis & Cancer Research Sub-Category: Glycobiology Gene Symbol: ARSB, MPS6 UniProt Number: P15848
MABC975
100 µL  
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      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IH(P)MCulture SupernatantMonoclonal Antibody
      Description
      Catalogue NumberMABC975
      DescriptionAnti-Arylsulfatase B Antibody, clone 10G6.1
      Alternate Names
      • Arylsulfatase B
      • ASB
      • G4S
      • N-acetylgalactosamine-4-sulfatase
      Background InformationArylsulfatase B (EC 3.1.6.12; UniProt P15848; also known as ASB, G4S, N-acetylgalactosamine-4-sulfatase) is encoded by the ARSB (also known as MPS6) gene (Gene ID 411) in human. Arylsulfatases consistute a group of enzymes found in the lysosomes of the liver, pancreas, and kidneys. Arylsulfatase B mediates the breakdown of two glycosaminoglycans (GAGs), dermatan sulfate and chondroitin sulfate. Arylsulfatase B-catalyzed removal of sulfate groups from chondroitin-4-sulfate (C4S) leads to the degradation of C4S. Cellular arylsulfatase B expression is also reported to be found in non-lysosomal compartments, including the plasma membrane. Arylsulfatase B is initially produced with a signal peptide sequence (a.a. 1-36), the removal of which yields the mature enzyme. Arylsulfatase B-deficiency due to ARSB mutations results in an accumulation of GAGs in lysosomes, which in turn can lead to Maroteaux–Lamy syndrome or mucopolysaccharidosis VI (MPS6).
      References
      Product Information
      FormatCulture Supernatant
      PresentationMouse monoclonal IgG2aκ antibody in tissue culture supernatant without preservatives.
      Quality LevelMQ100
      Applications
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Arylsulfatase B in human cerebral cortex and kidney tissues.
      Biological Information
      ImmunogenGST-tagged recombinant human Arylsulfatase B N-terminal fragment.
      EpitopeN-terminal region.
      Clone10G6.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityExpected to react with both spliced isoforms of human Arylsulfatase B reported by UniProt (P15848-1 and P15848-2).
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ARSB
      • MPS6
      Purification MethodUnpurified
      UniProt Number
      Molecular Weight~46 kDa observed. Target bands appear larger than the calculated molecular weights of 56.0 kDa (isoform 1) and 42.3 kDa (isoform 2) due to glycosylation.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HepG2 cell lysate.

      Western Blotting Analysis: A 1:1,000 dilution of this antibody detected Arylsulfatase B in 10 µg of HepG2 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      MABC975 04055977311792