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MABF2745-25UG Anti-CD200R Antibody, clone OX-108

Anti-CD200R, clone OX-108, Cat. No. MABF2745, is a mouse monoclonal antibody that detects CD200R and is tested for use in Flow Cytometry, Immunofluorescence, Inhibition, Immunohistochemistry, and Surface Plasmon Resonance.

MABF2745-25UG
25 μg  
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      Descripción

      Replacement Information
      Description
      Catalogue NumberMABF2745-25UG
      DescriptionAnti-CD200R Antibody, clone OX-108
      Alternate Names
      • Cell surface glycoprotein CD200 receptor 1
      • CD200 cell surface glycoprotein receptor
      • Cell surface glycoprotein OX2 receptor 1
      • CD200R
      • CRTR2
      • MOX2R
      • OX2R
      • UNQ2522/PRO6015
      Background InformationCell surface glycoprotein CD200 receptor 1 (UniProt: Q8TD46; also known as CD200 cell surface glycoprotein receptor, Cell surface glycoprotein OX2 receptor 1) is encoded by the CD200R1 (also known as CD200R, CRTR2, MOX2R, OX2R, UNQ2522/PRO6015) gene (Gene ID: 131450) in human. CD200R is an inhibitory receptor that plays a crucial role in the regulation of immune responses. It is primarily involved in maintaining immune homeostasis by delivering inhibitory signals that downregulate inflammatory responses and prevent overactivation of the immune system. Upon binding with its ligand, CD200, CD200R transduces signals that inhibit the activation of macrophages, dendritic cells, and other immune cells, thereby promoting tolerance and preventing autoimmune reactions. CD200R is expressed on various immune cells, including macrophages, dendritic cells, neutrophils, and certain subsets of T cells and B cells. It is also found on some non-immune cells, such as neurons and endothelial cells. The expression of CD200R1 is generally upregulated in response to inflammatory stimuli and during certain stages of immune cell differentiation. CD200R is implicated in various autoimmune diseases, cancer, infectious and neurodegenerative diseases.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG1 in PBS without azide.
      Quality LevelMQ200
      Applications
      ApplicationAnti-CD200R, clone OX-108, Cat. No. MABF2745, is a mouse monoclonal antibody that detects CD200R and is tested for use in Flow Cytometry, Immunofluorescence, Inhibition, Immunohistochemistry, and Surface Plasmon Resonance.
      Key Applications
      • Flow Cytometry
      • Immunofluorescence
      • Inhibition
      • Immunohistochemistry
      • Surface plasmon resonance
      Application NotesTested Applications

      Surface Plasmon Resonance: A representative lot detected CD200R in surface plasmon resonance application (Hatherley, D., et al. (2004). Eur J Immunol. 34(6):1688-94).

      Immunohistochemistry Application: A representative lot detected CD200R in immunohistochemistry application (Koning, N., et al. (2009). J Neuropathol Exp Neurol. 68(2):159-67).

      Inhibition: A representative lot blocked ligand-receptor interactions in protein microarray application (Letarte, M., et al. (2005). BMC Biochem.1:6:2).

      Flow Cytometry Analysis: A representative lot detected CD200R in flow cytometry application (Wright, G.J., et al. (2003). J Immunol. 171(6):3034-46; Foster-Cuevas, M., et al. (2004). J Virol. 78(14):7667-76; Koning, N., et al. (2009). J Neuropathol Exp Neurol. 68(2):159-67).

      Immunofluorescence Analysis: A representative lot detected CD200R in immunofluorescence application (Letarte, M., et al. (2005). BMC Biochem.1:6:2).

      Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user.
      Biological Information
      ImmunogenFull-length, recombinant human CD200R.
      EpitopeExtracellular domain
      CloneOX-108
      Concentration0.5 mg/mL. Please refer to guidance on suggested starting dilutions and/or titers per application and sample type.
      HostMouse
      SpecificityClone OX-108 is a mouse monoclonal antibody that detects CD200R. It targets an epitope within the extracellular domain.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CD200R1
      Purification MethodProtein G purified
      UniProt Number
      Molecular WeightTarget molecular weight 39.04 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Flow Cytometry with human peripheral blood mononuclear cells (PBMCs).

      Flow Cytometry Analysis: 1.0 µg from a representative lot detected CD200R in one million human peripheral blood mononuclear cells (PBMCs).
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at -10°C to -25°C. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size25 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      MABF2745-25UG 04065272290289

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