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233170 Anti-CLOCK (11-30) Rabbit pAb

Anti-CLOCK (11-30) Rabbit pAb: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
233170
  
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Descripción

Replacement Information

Tabla espec. clave

Host
Rb
Description
Overview

This product has been discontinued.





Recognizes the ~100 kDa CLOCK protein.
Catalogue Number233170
Brand Family Calbiochem®
References
ReferencesKing, D.P. and Takahashi, J.S. 2000. Annu. Rev. Neurosci. 23, 713.
Darlington, T.K, et al. 1998. Science 280, 1599.
Gekakis, N., et al. 1998. Science 280, 1564.
Product Information
FormLiquid
FormulationIn PBS, BSA.
Preservative≤0.1% sodium azide
Applications
Key Applications Immunoblotting (Western Blotting)
Immunohistochemistry
Application NotesImmunoblotting (1:200)
Immunohistochemistry (1:1000)
Application CommentsVariables associated with assay conditions will dictate the optimal working dilution.
Biological Information
Immunogena synthetic peptide [SSIVDRDDSSIFDGLVEEDD(C)] corresponding to amino acids 11-30 of the human and mouse CLOCK protein
ImmunogenHuman and Mouse
HostRabbit
IsotypeIgG
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage -20°C
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Número de referencia GTIN
233170 0

Documentation

Anti-CLOCK (11-30) Rabbit pAb Certificados de análisis

CargoNúmero de lote
233170

Referencias bibliográficas

Visión general referencias
King, D.P. and Takahashi, J.S. 2000. Annu. Rev. Neurosci. 23, 713.
Darlington, T.K, et al. 1998. Science 280, 1599.
Gekakis, N., et al. 1998. Science 280, 1564.
Ficha técnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-July-2007 RFH
ApplicationImmunoblotting (1:200)
Immunohistochemistry (1:1000)
DescriptionImmunoaffinity purified rabbit polyclonal antibody. Recognizes the ~100 kDa CLOCK protein.
BackgroundRegulation of circadian rhythmicity is regulated at the genetic level by a protein-mediated autoregulatory feedback loop. In mammals, several genes that encode members of the basic helix-loop-helix (bHLH) PAS (PER-ARNT-SIM) transcription factor family have been shown to play a significant role in regulating circadian oscillations. Transactivation of CLOCK-induced genes is mediated via an E box enhancer (CACGTG) found upstream of target genes. CLOCK-BMAL1 heterodimers bind to E box regulatory elements and stimulate gene transcription. CLOCK has been shown to transactivate the mammalian homolog of Drosophila, PER. PER, in concert with the product of the mammalian timeless gene (TIM), negatively regulates its own transcription by blocking the activity of the CLOCK-BMAL transactivation complex.
HostRabbit
Immunogen speciesHuman and Mouse
Immunogena synthetic peptide [SSIVDRDDSSIFDGLVEEDD(C)] corresponding to amino acids 11-30 of the human and mouse CLOCK protein
IsotypeIgG
Specieshamster, human, mouse, rat
FormLiquid
FormulationIn PBS, BSA.
Preservative≤0.1% sodium azide
CommentsVariables associated with assay conditions will dictate the optimal working dilution.
Storage Avoid freeze/thaw
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Toxicity Standard Handling
ReferencesKing, D.P. and Takahashi, J.S. 2000. Annu. Rev. Neurosci. 23, 713.
Darlington, T.K, et al. 1998. Science 280, 1599.
Gekakis, N., et al. 1998. Science 280, 1564.