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AB15299-I Anti-Dendrin

Anti-Dendrin Antibody, Cat. No. AB15299-I, is a highly specific rabbit polyclonal antibody that targets Dendrin and has been tested in Immunohistochemistry (Paraffin) and Western Blotting.

Anti-Dendrin: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Research Category: Neuroscience Gene Symbol: DDN, KIAA0749 UniProt Number: O94850
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AB15299-I
100 μg  
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      Descripción

      Replacement Information

      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, H, RIH(P), WBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB15299-I
      ReplacesAB15299
      DescriptionAnti-Dendrin
      Alternate Names
      • DDN
      Background InformationDendrin (UniProt: O94850) is encoded by the DDN (also known as KIAA0749) gene (Gene ID: 23109) in human. Dendrin is a proline-rich cytoplasmic protein that was originally recognized in telencephalic dendrites of sleep-deprived rats. Dendrin is specifically expressed in the brain and in kidneys. In the brain, it interacts with alpha-actinin and possibly modulates the structure of the actin cytoskeleton. In kidney it plays a role in apoptosis of kidney glomerular podocytes. Dendrin contains two putative nuclear localization signals (NLSs) and three PPXY motifs that are conserved among human, rat, and mouse. Dendrin is reported to interact with alpha-actinin and Maguk with inverted orientation (MAGI) or synaptic scaffolding molecule (S-SCAM). Interaction with S-SCAM is shown to be responsible for the retention of dendrin in the cytoplasm of mammalian cells and prevent its nuclear import. In experimental glomerulonephritis, dendrin is shown to relocate from the slit diaphragms (SD) to the nucleus of injured podocytes. High-doses of TGF- 1 can directly promote the import of dendrin into the nucleus and in the nucleus Dendrin enhances staurosporine- and TGF- 1-mediated apoptosis. Acute nicotine treatment is reported to induce a rapid, but short-lived, expression of the dendritically targeted, corticolimbic mRNA dendrin in specific regions of adolescent brain. (Ref.: Schochet, TL et al (2008). Eur.J. Neurosci. 28(10):1967-79; Kremerskothen, J et al. (2006). J. Neurochem. 96(6):1659-66; Asanuma, K et al. (2007). Proc. Natl. Acad. Sci. USA. 104(24): 10134-39).
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Dendrin Antibody, Cat. No. AB15299-I, is a highly specific rabbit polyclonal antibody that targets Dendrin and has been tested in Immunohistochemistry (Paraffin) and Western Blotting.
      Key Applications
      • Immunohistochemistry (Paraffin)
      • Western Blotting
      Application NotesWestern Blotting Analysis: 2 µg/mL from a representative lot detected Dendrin in 10 µg of human hippocampus tissue lysate.

      Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected Dendrin in rat cerebral cortex, mouse cerebellum, and rat kidney tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to 17 amino acids from the N-terminal region of human Dendrin.
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityThis polyclonal antibody recognizes Dendrin in human, mouse, and rat. It targets an epitope of 17 amino acids from the N-terminal region.
      Species Reactivity
      • Mouse
      • Human
      • Rat
      Species Reactivity NoteHuman, Mouse, Rat.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • DDN
      • KIAA0749
      Purification MethodAffinity Purified
      UniProt Number
      Molecular Weight~70 kDa observed, 76 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in mouse hippocampus tissue lysate.

      Western Blotting Analysis: 2 µg/mL of this antibody detected Dendrin in 10 µg of mouse hippocampus tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      AB15299-I 04054839179044