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MABN2492-50UG Anti-Green/Red Cone Opsin Antibody, clone 7G8

Anti-Green Red Cone Opsin, clone 7G8, Cat. No. MABN2492, is a highly specific mouse monoclonal antibody that targets Medium-wave-sensitive opsin 1 and Long-wave-sensitive opsin 1 and has been tested for use in Immunohistochemistry (Paraffin).

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Research Category: Neuroscience Gene Symbol: OPN1MW, GCP, OPN1LW, RCP UniProt Number: P04001, P04000
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MABN2492-50UG
50 μg  
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      Descripción

      Replacement Information

      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN2492-50UG
      DescriptionAnti-Green/Red Cone Opsin Antibody, clone 7G8
      Alternate Names
      • Medium-wave-sensitive opsin 1
      • Green cone photoreceptor pigment
      • Green-sensitive opsin
      • GOP
      • Long-wave-sensitive opsin 1
      • Red-sensitive opsin
      • ROP)
      Background InformationMedium-wave-sensitive opsin 1/Long-wave-sensitive opsin 1 (UniProts: P04001; P04000; also known as Green cone photoreceptor pigment, Green-sensitive opsin, GOP/ Red cone photoreceptor pigment, Red-sensitive opsin, ROP) are encoded by the OPN1MW (also known as GCP)/OPN1LW (also known as RCP) genes in human. The full range of color discrimination in humans is based on the presence and function of three cone photoreceptors. Each cone type possesses a photo-sensitive pigment-protein complex consisting of 11-cis retinal and a unique opsin protein that gives sensitivity in the short (S cone, peak sensitivity about 420 nm), middle (M cone, peak sensitivity about 530 nm with polymorphism), and long (L cone, peak sensitivity about 560 nm with polymorphism) wavelengths of the light spectrum. Opsins are multi-pass membrane proteins that belongs to the G-protein coupled receptor 1 family. They consist of four extracellular, 7 helical, and four cytoplasmic domains. Genes for the three types of cone opsins and the rod photoreceptor rhodopsin gene seem to be homologous with varying amounts of conservation. Strongest conservation is between the middle (green) and long (red) wavelength sensitive pigments on the X chromosome, suggesting a relatively recent duplication/divergence event. The S cone (blue) opsin seems to have a stronger conservation with rhodopsin. Cone photoreceptor distribution in humans is dominated by the M and L cone pigments. Mutations in OPN1MW and OPN1LW genes are known to cause color blindness that is characterized by a dichromasy in which red and green are confused, without loss of luminance or shift or shortening of the spectrum. Some mutations also lead to cone dystrophy leading to progressive degeneration of the cone photoreceptor with some preservation of rod function. (Ref.: Neitz, M., and Neitz, J. (2000). Arch. Ophthalmol. 118(5); 691-700).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-Green Red Cone Opsin, clone 7G8, Cat. No. MABN2492, is a highly specific mouse monoclonal antibody that targets Medium-wave-sensitive opsin 1 and Long-wave-sensitive opsin 1 and has been tested for use in Immunohistochemistry (Paraffin).
      Key Applications
      • Immunohistochemistry (Paraffin)
      Biological Information
      ImmunogenFull-length purified green/red human opsin.
      Clone7G8
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 7G8 specifically detects human green/red opsin.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • OPN1MW
      • GCP
      • OPN1LW
      • RCP
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight40.58 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry (Paraffin) in human retina tissue sections.

      Immunohistochemistry (Paraffin) Analysis: A 1:250 dilution of this antibody detected Green/Red Cone Opsin in human retina tissue sections.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size50 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      MABN2492-50UG 04054839563232