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MABN2430 Anti-Kallikrein 7 (KLK7) Antibody, clone 83-1

Anti-Kallikrein 7 (KLK7), clone 83-1, Cat. No. MABN2430, is a highly specific mouse monoclonal antibody that targets Kallikrein-7 and has been tested in ELISA and Western Blotting.

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Research Category: Neuroscience Gene Symbol: KLK7, PRSS6, SCCE UniProt Number: P49862
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MABN2430
100 μg  
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      Descripción

      Replacement Information

      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, ELISAMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN2430
      DescriptionAnti-Kallikrein 7 (KLK7) Antibody, clone 83-1
      Alternate Names
      • Serine protease 6
      • EC 3.4.21.117
      • hK7
      • Stratum corneum chymotryptic enzyme
      • hSCCE
      Background InformationKallikrein-7 (UniProt: P49862; also known as hK7, KLK7, Serine protease 6, Stratum corneum chymotryptic enzyme, hSCCE) is encoded by the KLK7 (also known as PRSS6, SCCE) gene (Gene ID: 5650) in human. KLK7 is a chymotrypsin-like serine protease of the member of peptidase S1 family. It is synthesized with a signal peptide of 22 amino acids (aa 1-22) and a propeptide region (aa 23-29) that are subsequently cleaved to generate the mature form. Human KLK7 displays about 40 to 60% amino acid homology with other members of the family. It cleaves proteins with aromatic side chains in the P1 position. KLK7 is abundantly expressed in the skin and is also present in the brain, mammary gland, cerebellum, spinal cord, and kidney. Lower levels of expression have been reported in in salivary glands, uterus, thymus, thyroid, placenta, trachea, and testis. Its levels are shown to be up-regulated in ovarian carcinoma, especially late-stage serous carcinoma. Less differentiated tumors of more advanced stage show higher level KLK7 expression. KLK7 activity is inhibited by zinc and copper ions.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Sodium bicarbonate buffer, pH 8.2 with 0.02% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Kallikrein 7 (KLK7), clone 83-1, Cat. No. MABN2430, is a highly specific mouse monoclonal antibody that targets Kallikrein-7 and has been tested in ELISA and Western Blotting.
      Key Applications
      • Western Blotting
      • ELISA
      Application NotesELISA Analysis: A representative lot detected Kallikrein 7 (KLK7) in ELISA applications (Shan, S.J., et. al. (2006). Clin Chem. 52(10):1879-86; Kishi, T., et. al. (2004). Clin Chem. 50(4):709-16).
      Biological Information
      ImmunogenFull-length human recombinant Kallikrein-7.
      Clone83-1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 83-1 detects Kallikrein -7 in human tissues.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • KLK7
      • PRSS6
      • SCCE
      UniProt Number
      Molecular Weight~27 kDa observed; 27.53 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human brain tissue lysate.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected Kallikrein 7 (KLK7) in 10 µg of human brain tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      MABN2430 04054839355592