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MABN449 Anti-Protein capicua homolog (CIC), clone 6E12.1 Antibody

This Anti-Protein capicua homolog (CIC), clone 6E12.1 Antibody is validated for use in Immunohistochemistry (Paraffin) for the detection of Protein capicua homolog (CIC).

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Research Category: Neuroscience Research Sub-Category: Developmental Signaling Gene Symbol: CIC UniProt Number: Q96RK0
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MABN449
100 µg  
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      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RIH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN449
      DescriptionAnti-Protein capicua homolog (CIC), clone 6E12.1 Antibody
      Alternate Names
      • Protein capicua homolog
      • Protein capicua homolog (CIC)
      Background InformationProtein capicua homolog (CIC) , also known as Capicua Transcriptional Repressor, Capicua Homolog, and encoded by the gene CIC, is a transcriptional repressor which plays a role in development of the central nervous system (CNS). CIC is a new subfamily of the HMG-box superfamily and the gene's expression is predominantly restricted to immature granule cells in the cerebellum, hippocampus and olfactory bulb in the CNS, and thus the gene is implicated in CNS development, in particular in granule cell development. CIC appears to be central to cerebellar development and ErbB signaling as well. Recent research has demonstrated that CIC is highly expressed in certain cancers including medulloblastomas, but also the loss of expression may serve as a biomarker for other cancer types such as oligodendrogliomas.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Protein capicua homolog (CIC), clone 6E12.1 Antibody is validated for use in Immunohistochemistry (Paraffin) for the detection of Protein capicua homolog (CIC).
      Key Applications
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:500-2,000 dilution from a representative lot detected Protein capicua homolog (CIC) in human cerebral cortex, rat olfactory bulb, and rat cerebral cortex tissue.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human Protein capicua homolog (CIC).
      Clone6E12.1
      Concentration1 mg/mL
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CIC
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight164 kDa calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in rat cerebellum tissue.

      Immunohistochemistry Analysis: A 1:500 dilution of this antibody detected Protein capicua homolog (CIC) in rat cerebellum tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      MABN449 04053252978845

      Documentation

      Anti-Protein capicua homolog (CIC), clone 6E12.1 Antibody Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Anti-Protein capicua homolog (CIC), clone 6E12.1 Antibody Certificados de análisis

      CargoNúmero de lote
      Anti-Protein capicua homolog (CIC), clone 6E12.1 3043515
      Anti-Protein capicua homolog (CIC), clone 6E12.1 - Q2435639 Q2435639
      Anti-Protein capicua homolog (CIC), clone 6E12.1 - 3671776 3671776
      Anti-Protein capicua homolog (CIC), clone 6E12.1 - 3836595 3836595