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MABN2426 Anti-TrpV2 Antibody, clone 2D6

Anti-TrpV2, clone 2D6 Antibody, Cat. No. MABN2426, is a highly specific mouse monoclonal antibody that targets TRPV2 and has been tested in Immunoprecipitation and Western Blotting.

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MABN2426
100 µL  
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      Descripción

      Replacement Information
      Description
      Catalogue NumberMABN2426
      DescriptionAnti-TrpV2 Antibody, clone 2D6
      Alternate Names
      • Transient receptor potential cation channel subfamily V member 2
      • Osm-9-like TRP channel 2
      • OTRPC2
      • Stretch-activated channel 2B
      • Vanilloid receptor-like protein 1
      • VRL-1
      Background InformationTransient receptor potential cation channel subfamily V member 2 (UniProt: Q9WUD2; also known as TrpV2, Osm-9-like TRP channel 2, OTRPC2, Stretch-activated channel 2B, Vanilloid receptor-like protein 1, VRL-1) is encoded by the Trpv2 (also known as Sac2b, Vrl1) gene (Gene ID: 29465) in murine species. TrpV2 is an ubiquitously expressed, calcium-permeable, non-selective cation channel with an outward rectification. It has been implicated in various physiological and pathological processes, including growth factor signaling, macrophage migration, cancer cell metastasis, heart disease, and neuronal cell development. It appears to be regulated by growth factors, like IGF1, PDGF, and morphogenetic neuropeptide/head activator. It is also activated by temperatures higher than 52C, but is not activated by vanilloids and acidic pH. TrpV2 channel is upregulated by the nerve growth factor (NGF) via the mitogen-activated protein kinase (MAPK) signaling pathway to augment neurite outgrowth. Although NGF increases TrpV2 content, it does not induce the translocation of TrpV2 from cytoplasm to cell surface in PC12 cells. (Ref.: Cohen MR et al. (2015). Mol. Cell Biol. 35(24): 4238-4252).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-TrpV2, clone 2D6 Antibody, Cat. No. MABN2426, is a highly specific mouse monoclonal antibody that targets TRPV2 and has been tested in Immunoprecipitation and Western Blotting.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Application NotesWestern Blotting Analysis: A reperesentative lot detected TrpV2 in Western Blotting applications (Cohen, M.R., et. al. (2013). PLoS One. 8(12):e85392; Cohen, M.R., et. al. (2015). Mol Cell Biol. 35(24):4238-52).

      Immunoprecipitation Analysis: A reperesentative lot detected TrpV2 in Immunoprecipitation applications (Cohen, M.R., et. al. (2013). PLoS One. 8(12):e85392).
      Biological Information
      ImmunogenA full length recombinant rat Transient receptor potential cation channel subfamily V member 2 (TrpV2).
      Clone2D6
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 2D6 detects Transient receptor potential cation channel subfamily V member 2 (TrpV2) in Hamster, Mouse, and Rat.
      IsotypeIgG1κ
      Species Reactivity
      • Rat
      • Hamster
      • Mouse
      Species Reactivity NoteHamster, Mouse, Rat.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Trpv2
      • Sac2b
      • Vrl1
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight~86 kDa observed; 86.71 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in PC12 cells treated with NGF.

      Western Blotting Analysis: A 1:500 dilution of this antibody detected TrpV2 in 10 µg of PC12 cells treated with NGF 7S (100 ng/72 hours).
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      MABN2426 04054839337147

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