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MABT1498-100UL Anti-ZDHHC13 Antibody, clone 26D1

Anti-ZDHHC13, clone 26D1, Cat. No. MABT1498, is a mouse monoclonal antibody that detects Palmitoyltransferase ZDHHC13 and has been tested for use in Western Blotting.

Anti-ZDHHC13 Antibody, clone 26D1: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Research Category: Neuroscience Gene Symbol: ZDHHC13, HIP14L, HIP3RP UniProt Number: Q8IUH4-2
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MABT1498-100UL
100 µL  
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      Descripción

      Replacement Information

      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABT1498-100UL
      DescriptionAnti-ZDHHC13 Antibody, clone 26D1
      Alternate Names
      • Palmitoyltransferase ZDHHC13
      • EC: 2.3.1.22
      • Huntingtin-interacting protein 14-related protein
      • HIP14-related protein
      • Huntingtin-interacting protein HIP3RP
      • Putative MAPK-activating protein PM03
      • Putative NF-kappa-B-activating protein 209
      • Zinc finger DHHC domain-containing protein 13
      • DHHC-13
      Background InformationPalmitoyltransferase ZDHHC13 (UniProt: Q8IUH4; also known as EC: 2.3.1.22, Huntingtin-interacting protein 14-related protein, HIP14-related protein, Huntingtin-interacting protein HIP3RP, Putative MAPK-activating protein PM03, Putative NF-kappa-B-activating protein 209, Zinc finger DHHC domain-containing protein 13, DHHC-13) is encoded by the ZDHHC13 (also known as HIP14L, HIP3RP) gene (Gene ID: 54503) in human. DHHC-13 is a multi-pass membrane protein that serves as a palmitoyl acyltransferase (PAT) specific for a subset of neuronal proteins, including HD and GAD2 and may play a role in the pathogenesis of Huntington disease (HD). It is reported to be dysfunctional in the presence of the HD mutation and HIP-14 deficient mice are shown to develop features of HD. DHHC-13 also plays a role in cellular magnesium homeostasis. It contains a DHHC domain (aa 426-476 in isoform 1 and 250-300 in isoform 2), which is required for its palmitoyltransferase activity. (Ref.: Young, FB et al. (2011). Prog. Neurobiol. 97(2); 220-238).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-ZDHHC13, clone 26D1, Cat. No. MABT1498, is a mouse monoclonal antibody that detects Palmitoyltransferase ZDHHC13 and has been tested for use in Western Blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenMBP-tagged recombinant fragment corresponding to 111 amino acids from the N-terminal region of human Palmitoyltransferase ZDHHC13, isoform 2.
      Clone26D1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 26D1 detects human Palmitoyltransferase ZDHHC13. It targets an epitope within 111 amino acids from the N-terminal region of isoforms 1 and 2. This sequence is conserved in both isoforms.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ZDHHC13
      • HIP14L
      • HIP3RP
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight~55 kDa observed; 56.51 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in A431 cell lysate.

      Western Blotting Analysis: A 1:500 dilution of this antibody detected ZDHHC13 in A431 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      MABT1498-100UL 04054839563409