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ABE269 Anti-acetyl-Histone H2B (Lys24) Antibody

Use Anti-acetyl-Histone H2B (Lys24) Antibody (Rabbit Polyclonal Antibody) validated in WB, IP, DB to detect acetyl-Histone H2B (Lys24) also known as H2BK24Ac, Histone H2B (acetyl K24).

Anti-acetyl-Histone H2B (Lys24) Antibody: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Histones Gene Symbol: HIST3H2BB UniProt Number: Q8N257
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ABE269
200 µL  
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      Tabla espec. clave

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWB, IP, DBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABE269
      DescriptionAnti-acetyl-Histone H2B (Lys24) Antibody
      Alternate Names
      • Histone H2B type 3-B
      • H2B type 12
      Background InformationChanges in chromatin structure play a large role in the regulation of transcription in eukaryotes (1). The nucleosome is the primary building block of chromatin, and is made up of four core histone proteins (H2A, H2B, H3 and H4) (2). Acetylation of core histones regulates gene expression (2). Histone H2B is primarily acetylated at lysines 5, 12, 15, and 20 (3). Ubiquitylation of Histone H2B at lysine 123 by Rad6 has been implicated in transcriptional activation and lysine methylation on histone H3 (4). Histone H2B phosphorylation at Ser10 (for yeast) and Ser14 (for mammalian cells) has been linked to regulation of apoptosis and meiosis (5).
      References
      Product Information
      FormatAffinity Purified
      Control
      • Recombinant Histone H2B protein, and untreated and sodium butyrate treated HeLa acid extracts
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ300
      Applications
      ApplicationUse Anti-acetyl-Histone H2B (Lys24) Antibody (Rabbit Polyclonal Antibody) validated in WB, IP, DB to detect acetyl-Histone H2B (Lys24) also known as H2BK24Ac, Histone H2B (acetyl K24).
      Key Applications
      • Western Blotting
      • Immunoprecipitation
      • Dot Blot
      Application NotesImmunoprecipitation Analysis: 10 μg from a representative lot immunoprecipitated acetyl-Histone H2B (Lys24) from HeLa acid extract.

      Dot Blot Specificity Analysis: Unmodified and various modified Histone peptides (see Table) were probed with Anti-acetyl-Histone H2B (Lys24) (1:500 dilution).
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human Histone H2B acetylated at Lys24.
      EpitopeAcetylated Lys24
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityThis antibody recognizes Histone H2B acetylated at Lys24.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • HIST3H2BB
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~16 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in recombinant Histone H2B protein, and untreated and sodium butyrate treated HeLa acid extracts.

      Western Blot Analysis: A 1:500 dilution of this antibody detected Histone H2B on 10 µg of recombinant Histone H2B protein, and untreated and sodium butyrate treated HeLa acid extracts.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      ABE269 04053252691911

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      Categorías

      Life Science Research > Antibodies and Assays > Primary Antibodies