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181305 Arcyriaflavin A, Synthetic - CAS 118458-54-1 - Calbiochem

This compound was originally isolated from the marine ascidian Eudistoma sp.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Primary Target: CDK4/D1
181305
  
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      Descripción

      Replacement Information

      Tabla espec. clave

      CAS #Empirical Formula
      118458-54-1C₂₀H₁₁N₃O₂
      Description
      Overview

      This product has been discontinued.





      This compound was originally isolated from the marine ascidian Eudistoma sp. Displays potent inhibitory activity against CDK4/D1 (IC50 = 59 nM). Also acts as a potent inhibitor of human cytomegalovirus (HCMV) replication in cell culture (IC50 = 200 nM).
      Catalogue Number181305
      Brand Family Calbiochem®
      References
      ReferencesZhu, G., et al. 2003. Bioorg. Med. Chem. Lett. 13, 1231.
      Slater, M.J., et al. 1999. Bioorg. Med. Chem. 7, 1067.
      Horton, P.A., et al. 1994. Experientia 50, 843.
      Product Information
      CAS number118458-54-1
      ATP CompetitiveN
      FormRed solid
      Hill FormulaC₂₀H₁₁N₃O₂
      Chemical formulaC₂₀H₁₁N₃O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetCDK4/D1
      Primary Target IC<sub>50</sub>59 nM against CDK4/D1
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      181305 0

      Documentation

      Licencias necesarias

      Título
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Arcyriaflavin A, Synthetic - CAS 118458-54-1 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Arcyriaflavin A, Synthetic - CAS 118458-54-1 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      181305

      Referencias bibliográficas

      Visión general referencias
      Zhu, G., et al. 2003. Bioorg. Med. Chem. Lett. 13, 1231.
      Slater, M.J., et al. 1999. Bioorg. Med. Chem. 7, 1067.
      Horton, P.A., et al. 1994. Experientia 50, 843.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-April-2011 RFH
      DescriptionA synthetic version of the natural compound originally isolated from the marine ascidian Eudistoma sp. Displays potent inhibitory activity against CDK4/cyclin D1 (IC50 = 59 nM). Also reported to inhibit human cytomegalovirus (HCMV) replication in cell culture (IC50 = 200 nM).
      FormRed solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number118458-54-1
      Chemical formulaC₂₀H₁₁N₃O₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesZhu, G., et al. 2003. Bioorg. Med. Chem. Lett. 13, 1231.
      Slater, M.J., et al. 1999. Bioorg. Med. Chem. 7, 1067.
      Horton, P.A., et al. 1994. Experientia 50, 843.