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504345 BX471 - CAS 217645-70-0 - Calbiochem

BX471 - CAS 217645-70-0 - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-urea, ZK-811752

Primary Target: CCR1
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      Descripción

      Replacement Information

      Tabla espec. clave

      CAS #Empirical Formula
      217645-70-0C₂₁H₂₄ClFN₄O₃
      Description
      OverviewAn orally active, selective antagonist for chemokine receptor 1 (CCR-1) (Ki = 1-5 nM). Has been used in studies related to intracellular calcium mobilization and migration of leukocytes mediated through CCR-1.
      Catalogue Number504345
      Brand Family Calbiochem®
      SynonymsN-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-urea, ZK-811752
      References
      ReferencesShahlaei, M., et al. 2011. J. Chemical Information and Modeling. 51, 2717.
      Reuss, R., et al. 2010. Mult Scler. 16, 366.
      Gladue, R., et al. 2010. Curr Top Med Chem 10, 1268.
      Vandemeulebroecke; M., et al. 2009. British J. of Clinical Pharmacol. 68, 435.
      Richard Horuk, R. 2005. Mini-Reviews in Medicinal Chemistry. 5, 791.
      Product Information
      CAS number217645-70-0
      FormWhite to beige powder
      Hill FormulaC₂₁H₂₄ClFN₄O₃
      Chemical formulaC₂₁H₂₄ClFN₄O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCCR1
      Primary Target K<sub>i</sub>1-5 nM
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      504345 0

      Documentation

      BX471 - CAS 217645-70-0 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      BX471 - CAS 217645-70-0 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      504345

      Referencias bibliográficas

      Visión general referencias
      Shahlaei, M., et al. 2011. J. Chemical Information and Modeling. 51, 2717.
      Reuss, R., et al. 2010. Mult Scler. 16, 366.
      Gladue, R., et al. 2010. Curr Top Med Chem 10, 1268.
      Vandemeulebroecke; M., et al. 2009. British J. of Clinical Pharmacol. 68, 435.
      Richard Horuk, R. 2005. Mini-Reviews in Medicinal Chemistry. 5, 791.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-April-2019 JSW
      SynonymsN-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-urea, ZK-811752
      DescriptionAn orally active, selective antagonist for chemokine receptor 1 (CCR-1) (Ki = 1-5 nM). Has been used in studies related to intracellular calcium mobilization and migration of leukocytes mediated through CCR-1.
      FormWhite to beige powder
      CAS number217645-70-0
      Chemical formulaC₂₁H₂₄ClFN₄O₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (≥25 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesShahlaei, M., et al. 2011. J. Chemical Information and Modeling. 51, 2717.
      Reuss, R., et al. 2010. Mult Scler. 16, 366.
      Gladue, R., et al. 2010. Curr Top Med Chem 10, 1268.
      Vandemeulebroecke; M., et al. 2009. British J. of Clinical Pharmacol. 68, 435.
      Richard Horuk, R. 2005. Mini-Reviews in Medicinal Chemistry. 5, 791.