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231180 CITCO

CITCO: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: 6-(4-Chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde-O-(3,4-dichlorobenzyl)oxime

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      Descripción

      Replacement Information

      Tabla espec. clave

      CAS #Empirical Formula
      338404-52-7C₁₉H₁₂Cl₃N₃OS
      Description
      Overview

      This product has been discontinued.





      A cell-permeable imidazothiazole compound that acts as a potent and selective agonist for the human orphan nuclear constitutive androstane receptor (CAR). Displays ~ 100-fold greater selectivity for CAR over xenobiotic pregnane X receptor (PXR) in transient transfection assays (EC50 = 25 nM vs. 3 µM) and shows no detectable activity on 15 other nuclear receptors tested even at concentrations as high as 10 µM.
      Catalogue Number231180
      Brand Family Calbiochem®
      Synonyms6-(4-Chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde-O-(3,4-dichlorobenzyl)oxime
      References
      ReferencesMaglich, J.M., et al. 2003. J. Biol. Chem. 278, 17277.
      Wang, H., and Negishi, M. 2003. Curr. Drug Metab. 4, 515.
      Product Information
      CAS number338404-52-7
      FormPale orange solid
      Hill FormulaC₁₉H₁₂Cl₃N₃OS
      Chemical formulaC₁₉H₁₂Cl₃N₃OS
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity≥98% by TLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      231180 0

      Documentation

      CITCO Certificados de análisis

      CargoNúmero de lote
      231180

      Referencias bibliográficas

      Visión general referencias
      Maglich, J.M., et al. 2003. J. Biol. Chem. 278, 17277.
      Wang, H., and Negishi, M. 2003. Curr. Drug Metab. 4, 515.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-April-2008 RFH
      Synonyms6-(4-Chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde-O-(3,4-dichlorobenzyl)oxime
      DescriptionA cell-permeable imidazothiazole compound that acts as a potent and selective agonist for the human orphan nuclear constitutive androstane receptor (CAR). Displays ~100-fold greater selectivity for CAR over xenobiotic pregnane X receptor (PXR) in transient transfection assays (EC50 = 25 nM vs. 3 µM, respectively). Does not exhibit detectable activity on 15 additional nuclear receptors tested, even at concentrations as high as 10 µM.
      FormPale orange solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number338404-52-7
      Chemical formulaC₁₉H₁₂Cl₃N₃OS
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesMaglich, J.M., et al. 2003. J. Biol. Chem. 278, 17277.
      Wang, H., and Negishi, M. 2003. Curr. Drug Metab. 4, 515.