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400010 Caspase-1 Inhibitor I - CAS 143313-51-3 - Calbiochem

The Caspase-1 Inhibitor I, also referenced under CAS 143313-51-3, controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: IL-1β Converting Enzyme (ICE) Inhibitor I, Ac-YVAD-CHO, L-709049

Primary Target: caspase-1, human recombinant
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      Descripción

      Replacement Information

      Tabla espec. clave

      CAS #Empirical Formula
      143313-51-3C₂₃H₃₂N₄O₈
      Description
      OverviewA potent, specific, and reversible inhibitor of caspase-1 (Ki = 200 pM for human recombinant caspase-1), caspase-4, and caspase-5. Strongly inhibits anti-APO-1 induced apoptosis in L929-APO-1 cells.
      Catalogue Number400010
      Brand Family Calbiochem®
      SynonymsIL-1β Converting Enzyme (ICE) Inhibitor I, Ac-YVAD-CHO, L-709049
      References
      ReferencesGarcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
      Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Los, M., et al. 1995. Nature 375, 81.
      Walker, N.P.C., et al. 1994. Cell 78, 343.
      Wilson, K.P., et al. 1994. Nature 370, 270.
      Thornberry, N.A., et al. 1992. Nature 356, 768.
      Product Information
      CAS number143313-51-3
      ATP CompetitiveN
      FormWhite powder
      Hill FormulaC₂₃H₃₂N₄O₈
      Chemical formulaC₂₃H₃₂N₄O₈
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetcaspase-1, human recombinant
      Primary Target K<sub>i</sub>200 pM for human recombinant caspase-1
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceAc-Tyr-Val-Ala-Asp-CHO
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      400010 0

      Documentation

      Caspase-1 Inhibitor I - CAS 143313-51-3 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Caspase-1 Inhibitor I - CAS 143313-51-3 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      400010

      Referencias bibliográficas

      Visión general referencias
      Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
      Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Los, M., et al. 1995. Nature 375, 81.
      Walker, N.P.C., et al. 1994. Cell 78, 343.
      Wilson, K.P., et al. 1994. Nature 370, 270.
      Thornberry, N.A., et al. 1992. Nature 356, 768.

      Folleto

      Cargo
      Caspases and other Apoptosis Related Tools Brochure
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-July-2014 JSW
      SynonymsIL-1β Converting Enzyme (ICE) Inhibitor I, Ac-YVAD-CHO, L-709049
      DescriptionInterleukin-1β converting enzyme (ICE) is a cysteine protease that cleaves the IL-1β precursor to mature IL-1β. ICE inhibitor I is a potent, specific, and reversible inhibitor of ICE (Ki = 200 pM for human recombinant ICE). Strongly inhibits anti-APO-1 induced apoptosis in L929-APO-1 cells.
      FormWhite powder
      CAS number143313-51-3
      Chemical formulaC₂₃H₃₂N₄O₈
      Peptide SequenceAc-Tyr-Val-Ala-Asp-CHO
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (5 mg/ml) or H₂O
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesGarcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
      Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Los, M., et al. 1995. Nature 375, 81.
      Walker, N.P.C., et al. 1994. Cell 78, 343.
      Wilson, K.P., et al. 1994. Nature 370, 270.
      Thornberry, N.A., et al. 1992. Nature 356, 768.

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      Categorías

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Apoptosis/Necrosis Inhibitors > Caspase Inhibitors