Millipore Sigma Vibrant Logo

855079 DHP HM resin (100-200 mesh)

Novabiochem®

DHP HM resin (100-200 mesh): Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Nº CAS: 9003-70-7
View Products on Sigmaaldrich.com
855079
Ver precios y disponibilidad

Descripción

Replacement Information

Tabla espec. clave

CAS #
9003-70-7
Descripción
Número de catálogo855079
Replaces01-64-0192
Marca de familia Novabiochem®
Alternate Names
  • 3,4-Dihydro-2H-pyran-2-yl-methoxymethyl polystyrene (100-200 mesh)
  • Ellman's dihydropyran resin
Información preliminarA highly versatile support for the solid phase immobilization of primary, secondary alcohols [1-11], phenols [12], purines [13], and indoles [14]. Derivatization is effected by treating the support in DCM with an excess of alcohol in the presence of a catalytic amount of pyridinium p-toluenesulfonate. A similar DHP-based support has also been used for the immobilization of tetrazoles [15].

Release of the product alcohol from the support has been carried out by treating with 95% TFA/5% water [1] and TFA/DCM/EtOH [2, 12]. However, the use of TFA can lead, in some cases, to trifluoroacetate formation. Methods which eliminate this potential side reaction include PPTS/BuOH/DCE [3], TosOH in DCM [16] and TosOH in DCE/BuOH [17].

The product number for this product was previously 01-64-0192.

To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".
Referencias bibliográficas
Información del producto
Número de CAS9003-70-7
Código HS 3907 29 90
Imagen fórmula estructuralImagen fórmula estructural
Quality LevelMQ200
Aplicaciones
Información biológica
Información fisicoquímica
Dimensiones
Información de materiales
Información toxicológica
Información de seguridad según el GHS
Clase de almacenamiento10 - 13 Otros liquidos y sustancias sólidas
WGKWGK 1 contamina ligeramente el agua
Información de seguridad
Declaraciones de uso del producto
Información de almacenamiento y transporte
AlmacenamientoAlmacenar entre +2°C y +8°C.
Información sobre embalaje
Información de transporte
Información complementaria
Especificaciones
Color (visual)slight yellow to beige
Appearance of substance (visual)beads
Loading (determined from the substitution of the Fmoc-Gly-ol loaded resin)0.70 - 1.20 mmol/g
Swelling Volume (in CH₂Cl₂)lot specific result
The polymer matrix is copoly (styrene-1% DVB), 100 - 200 mesh

Documentation

DHP HM resin (100-200 mesh) Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Citas

Título
  • [1] L. A. Thompson & J. A. Ellman (1994) Tetrahedron Lett., 35, 9333.
  • [2] O. B. Wallace (1997) Tetrahedron Lett., 38, 4939.
  • [3] G. Liu & J. A. Ellman (1995) J. Org. Chem., 60, 7712.
  • [4] E. K. Kick & J. A. Ellman (1995) J. Med. Chem., 38, 1427.
  • [5] J. S. Koh & J. A. Ellman (1996) J. Org. Chem., 61, 4494.
  • [6] J. Cossy, et al. (2000) Synlett, 3, 409.
  • [7] M. Ramaseshan, et al. (2000) J. Comb. Chem., 2, 615.
  • [8] M. Ramaseshan, et al. (2000) Tetrahedron Lett., 41, 4743.
  • [9] A. Bianco, et al. (2000) J. Org. Chem., 65, 2179.
  • [10] M. Steger, et al. (2001) Bioorg. Med. Chem. Lett., 11, 2537.
  • [11] A. Dahlgren, et al. (2003) Bioorg. Med.Chem. Lett., 11, 827.
  • [12] W. H. Pearson & R. B. Clark (1997) Tetrahedron Lett., 38, 7669.
  • [13] D. A. Nugiel, et al. (1997) J. Org. Chem., 62, 201.
  • [14] A. L. Smith, et al. (1998) Tetrahedron Lett., 39, 8317.
  • [15] S.-E. Yoo, et al. (1997) Tetrahedron Lett., 38, 1203.
  • [16] J. Beythien (Merck Biociences AG), personal communication.
  • [17] M. R. Tremblay, et al. (1999) Bioorg. Med. Chem. Lett., 9, 2827.