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317290 Diminutol

A cell-permeable 2,6,9-trisubstituted purine analog that blocks mitotic spindle assembly by competitively inhibiting NQO1, an NADP-dependent oxidoreductase.

Diminutol: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: 2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-aminophenylthio)-9-isopropylpurine, Diminisher of microtubule, NG72

Primary Target: NQO1, an NADP-dependent oxidoreductase
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      Descripción

      Replacement Information

      Tabla espec. clave

      CAS #Empirical Formula
      361431-33-6C₁₉H₂₆N₆OS
      Description
      Overview

      This product has been discontinued.





      A cell-permeable 2,6,9-trisubstituted purine analog that blocks mitotic spindle assembly by competitively inhibiting NQO1, an NADP-dependent oxidoreductase. Shown to interact with the NADP binding site and directly affect tubulin polymerization. Does not induce oxidative stress or affect the activity of Cdk1, DNA replication, or actin polymerization. Shown to cause significant microtubule depolymerization in Xenopus XL177 cells at 50 µM.
      Catalogue Number317290
      Brand Family Calbiochem®
      Synonyms2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-aminophenylthio)-9-isopropylpurine, Diminisher of microtubule, NG72
      References
      ReferencesWignall, S.M., et al. 2004. Chem. Biol. 11, 135.
      Product Information
      CAS number361431-33-6
      ATP CompetitiveN
      FormOff-white solid
      Hill FormulaC₁₉H₂₆N₆OS
      Chemical formulaC₁₉H₂₆N₆OS
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetNQO1, an NADP-dependent oxidoreductase
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Harmful
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      317290 0

      Documentation

      Diminutol Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Diminutol Certificados de análisis

      CargoNúmero de lote
      317290

      Referencias bibliográficas

      Visión general referencias
      Wignall, S.M., et al. 2004. Chem. Biol. 11, 135.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-June-2008 RFH
      Synonyms2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-aminophenylthio)-9-isopropylpurine, Diminisher of microtubule, NG72
      DescriptionA cell-permeable purine analog that blocks mitotic spindle assembly by competitively inhibiting NQO1, an NADP-dependent oxidoreductase. Shown to interact with the NADP binding site and directly affect tubulin polymerization. Does not induce oxidative stress or affect the activity of Cdk1, DNA replication, or actin polymerization. Shown to cause significant microtubule depolymerization in Xenopus XL177 cells at 50 µM.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number361431-33-6
      Chemical formulaC₁₉H₂₆N₆OS
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (20 mg/ml), Methanol or Chloroform
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      ReferencesWignall, S.M., et al. 2004. Chem. Biol. 11, 135.