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344930 Furin Inhibitor I - Calbiochem

Furin Inhibitor I, is a peptidyl chloromethylketone that binds to the catalytic site of furin and blocks its activity.

Furin Inhibitor I - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: Decanoyl-RVKR-CMK

Primary Target: viral glycoproteins
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344930
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Descripción

Replacement Information

Tabla espec. clave

Empirical Formula
C₃₄H₆₆ClN₁₁O₅

Precios y disponibilidad

Número de referencia DisponiblidadEmbalaje Cant./Env. Precio Cantidad
344930-150MG
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      344930-1MG
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          El resto: se avisará
          Se avisará
          Póngase en contacto con el Servicio de Atención al Cliente
          Contact Customer Service

          		 Ampolla de plást. 1 mg
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          No pudo obtenerse el precio
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          Description
          OverviewA peptidyl chloromethylketone that binds to the catalytic site of furin and blocks its activity. Hence, it can be used as a high specificity cleavage inhibitor of viral glycoproteins and blocker of viral replication. Reported to block the shedding of MT5-MMP by furin and prevent the activation of MT5-MMP. Also shown to reduce the pro-peptide cleavage of BACE (β-site APP-cleaving enzyme).
          Catalogue Number344930
          Brand Family Calbiochem®
          SynonymsDecanoyl-RVKR-CMK
          References
          ReferencesSugrue, R.J., et al. 2001. J. Gen. Virol. 82, 1375.
          Wang, X., and Pei, D. 2001. J. Biol. Chem. 276, 35953.
          Capell, A., et al. 2000. J. Biol. Chem. 275, 30849.
          Denault, J.B., et al. 1995. FEBS Lett. 362, 276.
          Denault, J.B., et al. 1995. J. Cardiovasc. Pharmacol. 26, S47.
          Garten, W., et al. 1994. Biochimie 76, 217.
          Hallenberger, S., et al. 1992. Nature 360, 358.
          Stieneke-Gröber, A., et al. 1992. EMBO J. 11, 2407.
          Product Information
          FormOff-white solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₃₄H₆₆ClN₁₁O₅
          Chemical formulaC₃₄H₆₆ClN₁₁O₅
          HS Code2925 29 90
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary Targetviral glycoproteins
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceDecanoyl-Arg-Val-Lys-Arg-CMK
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Número de referencia GTIN
          344930-150MG 04055977194388
          344930-1MG 04055977194371

          Documentation

          Furin Inhibitor I - Calbiochem Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Furin Inhibitor I - Calbiochem Certificados de análisis

          CargoNúmero de lote
          344930

          Referencias bibliográficas

          Visión general referencias
          Sugrue, R.J., et al. 2001. J. Gen. Virol. 82, 1375.
          Wang, X., and Pei, D. 2001. J. Biol. Chem. 276, 35953.
          Capell, A., et al. 2000. J. Biol. Chem. 275, 30849.
          Denault, J.B., et al. 1995. FEBS Lett. 362, 276.
          Denault, J.B., et al. 1995. J. Cardiovasc. Pharmacol. 26, S47.
          Garten, W., et al. 1994. Biochimie 76, 217.
          Hallenberger, S., et al. 1992. Nature 360, 358.
          Stieneke-Gröber, A., et al. 1992. EMBO J. 11, 2407.
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-June-2008 RFH
          SynonymsDecanoyl-RVKR-CMK
          DescriptionA peptidyl chloromethylketone that binds irreversibly to the catalytic site of furin and blocks its activity. Hence, it can be used as a high specificity cleavage inhibitor of viral glycoproteins and blocker viral replication. Reported to block the shedding of MT5-MMP by furin and prevent the activation of MT5-MMP. Completely inhibits the cleavage of Boc-RVRR-AMC (50 µM) by purified furin or PACE4. Also inhibits the activity of endothelin converting enzyme and reduces the pro-peptide cleavage of BACE (β-site APP-cleaving enzyme).
          FormOff-white solid
          FormulationSupplied as a trifluoroacetate salt.
          Chemical formulaC₃₄H₆₆ClN₁₁O₅
          Peptide SequenceDecanoyl-Arg-Val-Lys-Arg-CMK
          Structure formulaStructure formula
          Purity≥90% by HPLC
          SolubilityDMSO or Methanol (1 mg/ml)
          Storage Protect from moisture
          -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Standard Handling
          ReferencesSugrue, R.J., et al. 2001. J. Gen. Virol. 82, 1375.
          Wang, X., and Pei, D. 2001. J. Biol. Chem. 276, 35953.
          Capell, A., et al. 2000. J. Biol. Chem. 275, 30849.
          Denault, J.B., et al. 1995. FEBS Lett. 362, 276.
          Denault, J.B., et al. 1995. J. Cardiovasc. Pharmacol. 26, S47.
          Garten, W., et al. 1994. Biochimie 76, 217.
          Hallenberger, S., et al. 1992. Nature 360, 358.
          Stieneke-Gröber, A., et al. 1992. EMBO J. 11, 2407.