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361515 Glycogen Phosphorylase Inhibitor - CAS 648926-15-2 - Calbiochem

The Glycogen Phosphorylase Inhibitor, also referenced under CAS 648926-15-2, controls the biological activity of Glycogen Phosphorylase.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: 1-(3-(3-(2-Chloro-4,5-difluorobenzoyl)ureido)-4-methoxyphenyl)-3-methylurea

Primary Target: Glycogen phosphorylase
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361515
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
648926-15-2C₁₇H₁₅ClF₂N₄O₄

Precios y disponibilidad

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361515-1MG
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      361515-5MG
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          Description
          OverviewA cell-permeable urea compound that acts as a potent and AMP-competitive inhibitor of glycogen phosphorylase (GP; IC50 = 53 nM). Shown to inhibit glucagon-induced glyocgenolysis both in hepatocytes (IC50 = 380 nM) in vitro and in rats (5 mg/kg, iv) in vivo.
          Catalogue Number361515
          Brand Family Calbiochem®
          Synonyms1-(3-(3-(2-Chloro-4,5-difluorobenzoyl)ureido)-4-methoxyphenyl)-3-methylurea
          References
          ReferencesKlabunde, T., et al. 2005. J. Med. Chem. 48, 6178
          Product Information
          CAS number648926-15-2
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₇H₁₅ClF₂N₄O₄
          Chemical formulaC₁₇H₁₅ClF₂N₄O₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetGlycogen phosphorylase
          Primary Target IC<sub>50</sub>53 nM against glycogen phosphorylase
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Número de referencia GTIN
          361515-1MG 04055977192902
          361515-5MG 04055977192919

          Documentation

          Glycogen Phosphorylase Inhibitor - CAS 648926-15-2 - Calbiochem Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Glycogen Phosphorylase Inhibitor - CAS 648926-15-2 - Calbiochem Certificados de análisis

          CargoNúmero de lote
          361515

          Referencias bibliográficas

          Visión general referencias
          Klabunde, T., et al. 2005. J. Med. Chem. 48, 6178
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision01-July-2008 RFH
          Synonyms1-(3-(3-(2-Chloro-4,5-difluorobenzoyl)ureido)-4-methoxyphenyl)-3-methylurea
          DescriptionA cell-permeable urea compound that acts as a potent and AMP-competitive inhibitor of glycogen phosphorylase (GP; IC50 = 53 nM). Shown to inhibit glucagon-induced glyocgenolysis both in hepatocytes (IC50 = 380 nM) in vitro and in rats (5 mg/kg, iv) in vivo.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number648926-15-2
          Chemical formulaC₁₇H₁₅ClF₂N₄O₄
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (25 mg/ml)
          Storage Protect from light
          +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Irritant
          ReferencesKlabunde, T., et al. 2005. J. Med. Chem. 48, 6178