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420127 InSolution™ Jasplakinolide, Jaspis johnstoni - Calbiochem

InSolution™ Jasplakinolide, Jaspis johnstoni, CAS 102396-24-7, is a 1 mM solution of Jasplakinolide, Jaspis johnstoni in DMSO. Acts as a potent inducer of actin polymerization and stabilization.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Primary Target: F-actin
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420127
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Descripción

Replacement Information

Tabla espec. clave

Empirical Formula
C₃₆H₄₅BrN₄O₆

Precios y disponibilidad

Número de referencia DisponiblidadEmbalaje Cant./Env. Precio Cantidad
420127-50UG
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      Description
      Catalogue Number420127
      Brand Family Calbiochem®
      References
      ReferencesRosado, J.A., et al. 2000. J. Biol. Chem. 275, 7527.
      Posey, S.C., and Bierer, B.E. 1999. J. Biol. Chem. 274, 4259.
      Senderowicz, A.M., et al. 1995. J. Natl. Cancer Inst. 87, 46.
      Bubb, M.R., et al. 1994. J. Biol. Chem. 269, 14869.
      Scott, V.R., et al. 1988. Antimicrob. Agents Chemother. 32, 1154.
      Product Information
      ATP CompetitiveN
      FormLiquid
      FormulationA 1 mM (50 µg/71 µl) solution of Jasplakinolide, Jaspis johnstoni (Cat. No. 420107) in DMSO.
      Hill FormulaC₃₆H₄₅BrN₄O₆
      Chemical formulaC₃₆H₄₅BrN₄O₆
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationInSolution™ Jasplakinolide, Jaspis johnstoni, CAS 102396-24-7, is a 1 mM solution of Jasplakinolide, Jaspis johnstoni in DMSO. Acts as a potent inducer of actin polymerization and stabilization.
      Biological Information
      Primary TargetF-actin
      Primary Target IC<sub>50</sub>Kd = 15 nM for actin binding
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Harmful
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      420127-50UG 04055977188059

      Documentation

      Licencias necesarias

      Título
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      InSolution™ Jasplakinolide, Jaspis johnstoni - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      InSolution™ Jasplakinolide, Jaspis johnstoni - Calbiochem Certificados de análisis

      CargoNúmero de lote
      420127

      Referencias bibliográficas

      Visión general referencias
      Rosado, J.A., et al. 2000. J. Biol. Chem. 275, 7527.
      Posey, S.C., and Bierer, B.E. 1999. J. Biol. Chem. 274, 4259.
      Senderowicz, A.M., et al. 1995. J. Natl. Cancer Inst. 87, 46.
      Bubb, M.R., et al. 1994. J. Biol. Chem. 269, 14869.
      Scott, V.R., et al. 1988. Antimicrob. Agents Chemother. 32, 1154.

      Citas

      Título
    • Markus Utech, et al. (2005) Mechanism of IFN-γ-Induced Endocytosis of Tight Junction Proteins: Mysoin II-Dependent Vacuolarization of the Apical Plasma Membrane. Molecular Biology of the Cell 16, 5040-5052.
      		•
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-March-2008 JSW
      DescriptionA cell-permeable F-actin probe. This macrocyclic cyclodepsipeptide, isolated from the marine sponge Jaspis johnstoni, is a potent inducer of actin polymerization and stabilization in vitro. It competes with Phalloidin (Cat. No. 516640) for actin binding (Kd = 15 nM) and enhances apoptosis induced by interleukin 2 (IL-2) deprivation. Also displays fungicidal, insecticidal, and anticancer properties.
      FormLiquid
      FormulationA 1 mM (50 µg/71 µl) solution of Jasplakinolide, Jaspis johnstoni (Cat. No. 420107) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₃₆H₄₅BrN₄O₆
      Structure formulaStructure formula
      Purity≥90% by HPLC
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Toxicity Harmful
      ReferencesRosado, J.A., et al. 2000. J. Biol. Chem. 275, 7527.
      Posey, S.C., and Bierer, B.E. 1999. J. Biol. Chem. 274, 4259.
      Senderowicz, A.M., et al. 1995. J. Natl. Cancer Inst. 87, 46.
      Bubb, M.R., et al. 1994. J. Biol. Chem. 269, 14869.
      Scott, V.R., et al. 1988. Antimicrob. Agents Chemother. 32, 1154.
      Citation
    • Markus Utech, et al. (2005) Mechanism of IFN-γ-Induced Endocytosis of Tight Junction Proteins: Mysoin II-Dependent Vacuolarization of the Apical Plasma Membrane. Molecular Biology of the Cell 16, 5040-5052.
      		•