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508227 InSolution™ Paclitaxel, Taxus sp. - CAS 33069-62-4 - Calbiochem

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: TAXOL® InSolution, Baccatin III N-benzyl-β-phenylisoserine Ester

Primary Target: microtubules
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508227
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Replacement Information

Tabla espec. clave

CAS #Empirical Formula
33069-62-4C₄₇H₅₁NO₁₄

Precios y disponibilidad

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      Description
      Catalogue Number508227
      Brand Family Calbiochem®
      SynonymsTAXOL® InSolution, Baccatin III N-benzyl-β-phenylisoserine Ester
      References
      ReferencesDerry, W.B., et al. 1995. Biochemistry 34, 2203.
      Milas, L., et al. 1995. Cancer Chemother. Pharmacol. 35, 297.
      Donaldson, K.L., et al. 1994. Int. J. Cancer 57, 847.
      Hornback, N.B., et al. 1994. In Vivo 8, 819.
      Manthey, C.L., et al. 1992. J. Immunol. 149, 2459.
      Rowinsky, E.K., et al. 1992. Semin. Oncol. 19, 646.
      Ding, A.H., et al. 1990. Science 248, 370.
      Mogensen, M.M. and Tucker, J.B. 1990. J. Cell Sci. 97, 101.
      Slichenmeyer, W.J. and Von Hoff, D.D. 1990. J. Clin. Pharmacol. 30, 770.
      Product Information
      CAS number33069-62-4
      FormLiquid
      FormulationA 25 mM (10 mg/468 µL) sterile-filtered solution of Paclitaxel, Taxus sp. (Cat. No. 580555) in DMSO.
      Hill FormulaC₄₇H₅₁NO₁₄
      Chemical formulaC₄₇H₅₁NO₁₄
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetmicrotubules
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C. Use only fresh DMSO for further dilutions.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      5.08227.0001 04055977261783

      Documentation

      InSolution™ Paclitaxel, Taxus sp. - CAS 33069-62-4 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Referencias bibliográficas

      Visión general referencias
      Derry, W.B., et al. 1995. Biochemistry 34, 2203.
      Milas, L., et al. 1995. Cancer Chemother. Pharmacol. 35, 297.
      Donaldson, K.L., et al. 1994. Int. J. Cancer 57, 847.
      Hornback, N.B., et al. 1994. In Vivo 8, 819.
      Manthey, C.L., et al. 1992. J. Immunol. 149, 2459.
      Rowinsky, E.K., et al. 1992. Semin. Oncol. 19, 646.
      Ding, A.H., et al. 1990. Science 248, 370.
      Mogensen, M.M. and Tucker, J.B. 1990. J. Cell Sci. 97, 101.
      Slichenmeyer, W.J. and Von Hoff, D.D. 1990. J. Clin. Pharmacol. 30, 770.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-December-2013 JSW
      SynonymsTAXOL® InSolution, Baccatin III N-benzyl-β-phenylisoserine Ester
      DescriptionAntitumor and anti-leukemic agent isolated from the bark of the yew tree. Promotes assembly of microtubules and inhibits tubulin disassembly. An effective agent in blocking HeLa and B16 cells at the G2/M stage. Inhibits DNA synthesis and stimulates the release of tumor necrosis factor-α. Induces apoptosis in murine mammary carcinoma MCA-4 and ovarian carcinoma OCA-1 tumors.
      FormLiquid
      FormulationA 25 mM (10 mg/468 µL) sterile-filtered solution of Paclitaxel, Taxus sp. (Cat. No. 580555) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number33069-62-4
      Chemical formulaC₄₇H₅₁NO₁₄
      Structure formulaStructure formula
      Purity≥97% by HPLC
      Storage Protect from light
      Avoid freeze/thaw
      ≤ -70°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C. Use only fresh DMSO for further dilutions.
      Toxicity Standard Handling
      ReferencesDerry, W.B., et al. 1995. Biochemistry 34, 2203.
      Milas, L., et al. 1995. Cancer Chemother. Pharmacol. 35, 297.
      Donaldson, K.L., et al. 1994. Int. J. Cancer 57, 847.
      Hornback, N.B., et al. 1994. In Vivo 8, 819.
      Manthey, C.L., et al. 1992. J. Immunol. 149, 2459.
      Rowinsky, E.K., et al. 1992. Semin. Oncol. 19, 646.
      Ding, A.H., et al. 1990. Science 248, 370.
      Mogensen, M.M. and Tucker, J.B. 1990. J. Cell Sci. 97, 101.
      Slichenmeyer, W.J. and Von Hoff, D.D. 1990. J. Clin. Pharmacol. 30, 770.