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438210 LSF Inhibitor, FQI1 - Calbiochem

The LSF Inhibitor, FQI1 controls the biological activity of LSF.

LSF Inhibitor, FQI1 - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: (±)(8-(2-Ethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]quinolin-6(5H)-one, Factor Quinolinone Inhibitor 1, Racemic

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438210
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Descripción

Replacement Information

Tabla espec. clave

Empirical Formula
C₁₈H₁₇NO₄

Precios y disponibilidad

Número de referencia DisponiblidadEmbalaje Cant./Env. Precio Cantidad
438210-10MG
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      Description
      OverviewA cell-permeable dihydroquinolinone compound that acts as a potent, specific, and reversible inhibitor of DNA-binding activity of Late SV40 Factor (LSF) and blocks LSF transactivation (IC50 = 2.1 µM in NIH 3T3 cells). Exhibits anti-proliferative activity and growth arrest in multiple cell lines (GI50 = 3.8, 0.79, and 6.3 µM in NIH 3T3, HeLa S3 and A549 cells, respectively). Shown to induce apoptotic cell death in liver cancer cell lines over-expressing LSF without affecting primary or immortalized hepatocytes. Also shown to inhibit hepatocellular carcinoma s.c. growth in mouse xenograft model without any toxic effects (1 mg/kg, i.p., once every 3 days).
      Catalogue Number438210
      Brand Family Calbiochem®
      Synonyms(±)(8-(2-Ethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]quinolin-6(5H)-one, Factor Quinolinone Inhibitor 1, Racemic
      Application Data
      References
      ReferencesGrant, T.J., et al. 2012. Proc. Natl. Acad. Sci. USA 109, 4503.
      Product Information
      FormWhite powder
      Hill FormulaC₁₈H₁₇NO₄
      Chemical formulaC₁₈H₁₇NO₄
      Quality LevelMQ100
      Applications
      Biological Information
      Purity>92% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      438210-10MG 04055977187052

      Documentation

      LSF Inhibitor, FQI1 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      LSF Inhibitor, FQI1 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      438210

      Referencias bibliográficas

      Visión general referencias
      Grant, T.J., et al. 2012. Proc. Natl. Acad. Sci. USA 109, 4503.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision21-September-2012 JSW
      Synonyms(±)(8-(2-Ethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]quinolin-6(5H)-one, Factor Quinolinone Inhibitor 1, Racemic
      Application Data
      DescriptionA cell-permeable dihydroquinolinone compound that acts as a potent, specific, and reversible inhibitor of DNA-binding activity of Late SV40 Factor (LSF) and blocks LSF transactivation (IC50 = 2.1 µM in NIH 3T3 cells). Exhibits anti-proliferative activity and growth arrest in multiple cell lines (GI50 = 3.8, 0.79, and 6.3 µM in NIH 3T3, HeLa S3 and A549 cells, respectively). Shown to induce apoptotic cell death in liver cancer cell lines over-expressing LSF without affecting primary or immortalized hepatocytes. Also shown to inhibit hepatocellular carcinoma s.c. growth in mouse xenograft model without any toxic effects (1 mg/kg, i.p., once every 3 days).
      FormWhite powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₈H₁₇NO₄
      Purity>92% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesGrant, T.J., et al. 2012. Proc. Natl. Acad. Sci. USA 109, 4503.