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855059 Merrifield resin LL (100-200 mesh)

Novabiochem®

Merrifield resin LL (100-200 mesh): Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Nº CAS: 9003-70-7
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855059
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Descripción

Replacement Information

Tabla espec. clave

CAS #
9003-70-7
Descripción
Número de catálogo855059
Replaces01-64-0008
Marca de familia Novabiochem®
Alternate Names
  • Chloromethylpolystyrene-divinylbenzene (100-200 mesh)
Información preliminarMerrifield resin was the standard support for the synthesis of peptide acids by Boc SPPS [1, 2]. In peptide chemistry, it is now really only used in the synthesis of small to medium sized peptides, as the benzylic ester resin linkage is not completely stable towards repetitive treatment with TFA.

Attachment of the C-terminal residue is generally achieved by heating the resin in DMF with the appropriate amino acid cesium salt in the presence of KI [3]; although, Me4N salts [4], sodium salts [5] in THF with Bu4NF catalysis [6] and zinc salts in EtOH have also been used [7].

Cleavage is normally effected by treatment of resin with HF or TFMSA, or by hydrogenolysis [8]. Alcohols can be released using reducing agents such as DIBAL [6] or LiBH4 [9]. Methyl esters can be produced by transesterification with methoxide [10].

The product number for this product was previously 01-64-0008.

To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".
Referencias bibliográficas
Información del producto
Número de CAS9003-70-7
Código HS 3903 90 90
Imagen fórmula estructuralImagen fórmula estructural
Quality LevelMQ200
Aplicaciones
Información biológica
Información fisicoquímica
Dimensiones
Información de materiales
Información toxicológica
Información de seguridad según el GHS
Clase de almacenamiento10 - 13 Otros liquidos y sustancias sólidas
WGKWGK 1 contamina ligeramente el agua
Información de seguridad
Declaraciones de uso del producto
Información de almacenamiento y transporte
AlmacenamientoAlmacenar por debajo de +30°C.
Información sobre embalaje
Información de transporte
Información complementaria
Especificaciones
Color (visual)white to yellow to beige
Appearance of substance (visual)beads
Loading (determined by elemental analysis for sulfur after derivatization with KSAc)0.40 - 1.10 mmol/g
Swelling Volume (in CH₂Cl₂)lot specific result
The polymer matrix is copoly (styrene-1 % DVB), 100 -200 mesh (75 - 150 µm)

Documentation

Merrifield resin LL (100-200 mesh) Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Citas

Título
  • [1] M. Bodanszky, et al. in "Peptide Synthesis", E. Gross & J. Meienhofer (Eds), Academic Press, Y. Wiley, New York, 1976.
  • [2] G. Barany, et al. (1980) Peptides, 2, 1.
  • [3] B. F. Gisin (1973) Helv. Chim. Acta, 56, 1476.
  • [4] A. Loffet (1971) Int. J. Protein Res., 3, 297.
  • [5] S.-S. Wang (1975) J. Org. Chem., 40, 1235.
  • [6] M. J. Kurth, et al. (1994) J. Org. Chem., 59, 5862.
  • [7] M. V. Anuradha, et al. (1995) Tetrahedron, 51, 5671.
  • [8] J. M. Schlatter, et al. (1977) Tetrahedron Lett., 2851.
  • [9] J. M. Stewart, et al. (1981) , U.S. Patent 4,254,023.
  • [10] R. Frenette, et al. (1994) Proc. Natl. Acad. Sci. USA, 90, 6906.