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855029 N-Cyclohexylcarbodiimide,N'-methyl polystyrene

Novabiochem®

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Nº CAS: 9003-70-7
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855029
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Descripción

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CAS #
9003-70-7
Descripción
Número de catálogo855029
Replaces01-64-0211
Marca de familia Novabiochem®
Información preliminarN-Cyclohexylcarbodiimide,N'-methyl polystyrene [1] is an ideal tool for mediating solution phase coupling reactions. Typically, the amine and carboxylic acid are treated with a 2-3 fold excess of resin in DCM or DMF [2, 3]; a slight excess of carboxyl component over amine component is often used to help drive the reaction to completion. As excess acid and urea by-products remain attached to the resin at the end of the reaction, the product can normally be isolated pure by filtration and evaporation of the reaction mixture. Reactions can be accelerated by the addition of auxiliary nucleophiles such as HOBt; these can be removed using polyamine- or TBD-polystyrene. This resin has also been used in conjunction with DMAP to mediate ester formation [4].

The product number for this product was previously 01-64-0211.

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Referencias bibliográficas
Información del producto
Número de CAS9003-70-7
Código HS 3903 90 90
Imagen fórmula estructuralImagen fórmula estructural
Quality LevelMQ200
Aplicaciones
Información biológica
Información fisicoquímica
Dimensiones
Información de materiales
Información toxicológica
Información de seguridad según el GHS
Clase de almacenamiento10 - 13 Otros liquidos y sustancias sólidas
WGKWGK 1 contamina ligeramente el agua
Información de seguridad
Declaraciones de uso del producto
Información de almacenamiento y transporte
AlmacenamientoAlmacenar entre +2°C y +8°C.
Información sobre embalaje
Información de transporte
Información complementaria
Especificaciones
Color (visual)slightly beige to brown
Appearance of substance (visual)beads
Loading (determined by HPLC after reaction of Z-Phe-OH with cyclohexylamine)≥ 1.3 mmol/g
Swelling Volume (in CH₂Cl₂)lot specific result
The polymer matrix is copoly (styrene-2 % DVB), 200 - 400 mesh.

Documentation

N-Cyclohexylcarbodiimide,N'-methyl polystyrene Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Citas

Título
  • [1] G.M Weinshenker, et al. (1988) Org. Synth., Coll. Vol. VI, 951.
  • [2] Y. Guan, et al. (2000) J. Comb. Chem., 2, 297.
  • [3] K. Senton, et al. (2003) J. Comb. Chem., 5, 336.
  • [4] M. Cano, et al. (2002) J. Org. Chem., 67, 129.