Millipore Sigma Vibrant Logo

488004 Nodinitib-1 - Calbiochem

Nodinitib-1 - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: CID-1088438, 1-((4-Methylphenyl)sulfonyl)-1H-benzimidazol-2-amine, ML130, 1-(Toluene-4-sulfonyl)-1H-benzimidazol-2-ylamine, NOD1 Signaling Inhibitor, Nucleotide-binding Oligomerization Domain 1 Signaling Inhibitor

View Products on Sigmaaldrich.com
488004
  
Recuperando precio...
No pudo obtenerse el precio
La cantidad mínima tiene que ser múltiplo de
Maximum Quantity is
Al finalizar el pedido Más información
Ahorró ()
 
—
Solicitar precio
—
Disponibilidad a confirmar Disponibilidad a confirmar
Ingrese cantidad 
Suspendido
Cantidades limitadas disponibles
Debe confirmarse disponibilidad
    El resto: se avisará
      El resto: se avisará
      Se avisará
      Póngase en contacto con el Servicio de Atención al Cliente
      Contact Customer Service

       

      Póngase en contacto con el Servicio de Atención al Cliente

      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical Formula
      C₁₄H₁₃N₃O₂S
      Description
      Overview

      This product has been discontinued.



      A cell-permeable aminobenzimidazole compound that acts as a potent, specific and reversible inhibitor of NOD1 (Nucleotide-binding Oligomerization Domain 1; NLRC1, CARD4, or CLR7.1)-induced NF-κB activation (IC50 = 0.56 µM, >20, and >20 by NOD1 ligand, NOD2 ligand and TNFα in HEK293T-NF-κB-luciferase cells, respectively). Shown to block phosphorylation and degradation of IκBα and MAPK signaling (5 µM in HCT-116 cells) with no effect on Akt pathway. Suggested to directly interact with NOD1, alter the conformation and suppress RIP2 trafficking, a NOD1-binding partner required for NF-κB induction.
      Catalogue Number488004
      Brand Family Calbiochem®
      SynonymsCID-1088438, 1-((4-Methylphenyl)sulfonyl)-1H-benzimidazol-2-amine, ML130, 1-(Toluene-4-sulfonyl)-1H-benzimidazol-2-ylamine, NOD1 Signaling Inhibitor, Nucleotide-binding Oligomerization Domain 1 Signaling Inhibitor
      References
      ReferencesKhan, P.M., et al. 2011. ACS Med. Chem. Lett. 2, 780.
      Correa, R.G., et al. 2011. Chem. Biol. 18, 825.
      Product Information
      FormWhite powder
      Hill FormulaC₁₄H₁₃N₃O₂S
      Chemical formulaC₁₄H₁₃N₃O₂S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      488004 0

      Documentation

      Nodinitib-1 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Nodinitib-1 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      488004

      Referencias bibliográficas

      Visión general referencias
      Khan, P.M., et al. 2011. ACS Med. Chem. Lett. 2, 780.
      Correa, R.G., et al. 2011. Chem. Biol. 18, 825.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-June-2012 JSW
      SynonymsCID-1088438, 1-((4-Methylphenyl)sulfonyl)-1H-benzimidazol-2-amine, ML130, 1-(Toluene-4-sulfonyl)-1H-benzimidazol-2-ylamine, NOD1 Signaling Inhibitor, Nucleotide-binding Oligomerization Domain 1 Signaling Inhibitor
      DescriptionA cell-permeable aminobenzimidazole compound that acts as a potent, specific and reversible inhibitor of NOD1 (Nucleotide-binding Oligomerization Domain 1; NLRC1, CARD4, or CLR7.1)-induced NF-κB activation (IC50 = 0.56 µM, >20, and >20 by NOD1 ligand, NOD2 ligand and TNFα in HEK293T-NF-κB-luciferase cells, respectively). Shown to block phosphorylation and degradation of IκBα and MAPK signaling (5 µM in HCT-116 cells) with no effect on Akt pathway. Suggested to directly interact with NOD1, alter the conformation and suppress RIP2 trafficking, a NOD1-binding partner required for NF-κB induction.
      FormWhite powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₄H₁₃N₃O₂S
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (50 mg/ml; clear, colorless solution)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesKhan, P.M., et al. 2011. ACS Med. Chem. Lett. 2, 780.
      Correa, R.G., et al. 2011. Chem. Biol. 18, 825.