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855010 NovaSyn®TGT alcohol resin

Novabiochem®

NovaSyn®TGT alcohol resin: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Nº CAS: 478242-36-3
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855010
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Descripción

Replacement Information

Tabla espec. clave

CAS #
478242-36-3
Descripción
Número de catálogo855010
Replaces01-64-0066
Marca de familia Novabiochem®
Información preliminarNovaSyn® TGT alcohol resin is derived from TG amino resin by acylation with Bayer's 4-carboxytrityl linker [1]. Before use the resin must be converted to the chloride form by heating with AcCl [2, 3] or SOCl2 [4, 5] in toluene. The unstable trityl chloride resin should then be used immediately.

Attachment of α-amino acids is free from enantiomerization, making this support ideal for the immobilization of sensitive residues such as Cys and His.

Iodine oxidation of peptides containing Cys(Trt) occurs with release of the peptide from the resin.

This support is also ideally suited to the synthesis of prolyl peptides as the bulk of the trityl handle prohibits diketopiperazine formation [6].

Cleavage of protected peptide acids from this matrix can be effected by treatment with AcOH/MeOH/DCM [1], 0.5% TFA or HFIP [7].

The product number for this product was previously 01-64-0066.

To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".
Referencias bibliográficas
Información del producto
Número de CAS478242-36-3
Código HS 3903 90 90
Imagen fórmula estructuralImagen fórmula estructural
Quality LevelMQ200
Aplicaciones
Información biológica
Información fisicoquímica
Dimensiones
Información de materiales
Información toxicológica
Información de seguridad según el GHS
Clase de almacenamiento10 - 13 Otros liquidos y sustancias sólidas
WGKWGK 1 contamina ligeramente el agua
Información de seguridad
Declaraciones de uso del producto
Información de almacenamiento y transporte
AlmacenamientoAlmacenar entre +2°C y +8°C.
Información sobre embalaje
Información de transporte
Información complementaria
Especificaciones
Color (visual)white to yellow to beige
Appearance of substance (visual)beads
Loading (determined from the substitution of the Fmoc-Leu loaded resin)0.15 - 0.30 mmol/g
Swelling Volume (in CH₂Cl₂)lot specific result
The polymer matrix is NovaSyn TG resin (90 µm).

Documentation

NovaSyn®TGT alcohol resin Ficha datos de seguridad (MSDS)

Título

Ficha técnica de seguridad del material (MSDS) 

Citas

Título
  • [1] E. Bayer, et al. in 'Peptides, Chemistry, Structure & Biology, Proc. 13th American Peptide Symposium', R. S. Hodges & J. A. Smith (Eds), ESCOM, Leiden, 1994, pp. 156.
  • [2] J. M. J. Frechet, et al. (1975) Tetrahedron Lett., 3055.
  • [3] T. M. Fyles, et al. (1976) Can. J. Chem., 54, 935.
  • [4] A. v. Vliet, et al. in 'Innovation & Perspectives in Solid Phase Synthesis, 2nd International Symposium', R. Epton (Eds), Intercept UK Ltd., Andover, 1992, pp. 475.
  • [5] A. v. Vliet, et al. in 'Peptides 1992, Proc. 22nd European Peptide Symposium', C. H. Schneider & A. N. Eberle (Eds), ESCOM, Leiden, 1993, pp. 279.
  • [6] G. Grübler, et al. in 'Innovation & Perspectives in Solid Phase Synthesis, 3rd International Symposium', R. Epton (Eds), Mayflower Worldwide Ltd., Birmingham, 1994, pp. 517.
  • [7] R. Bollhagen, et al. (1994) J. Chem. Soc., Chem. Commun., 2559.