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512732 Parthenolide, Tanacetum parthenium - CAS 20554-84-1 - Calbiochem

A cell-permeable sesquiterpene lactone with anti-inflammatory, antisecretory, and spasmolytic properties.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Primary Target: the expression of COX-2 and proinflammatory cytokines (TNF-α and IL-1) in LPS-stimulated macrophages
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512732
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
20554-84-1C₁₅H₂₀O₃

Precios y disponibilidad

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512732-50MG
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      Description
      OverviewA cell-permeable sesquiterpene lactone with anti-inflammatory, antisecretory, and spasmolytic properties. Inhibits the expression of COX-2 and proinflammatory cytokines (TNF-α and IL-1) in LPS-stimulated macrophages. Also inhibits NF-κB and activation of MAP kinase.
      Catalogue Number512732
      Brand Family Calbiochem®
      References
      ReferencesWong, H.R., et al. 1999. Biochem. Biophys. Res. Comm.262, 375.
      Bork, P.M., et al. 1997. FEBS Lett. 402, 85.
      Hwang, D., et al. 1996. Biochem. Biophys. Res. Commun. 226, 810.
      Barsby, R.W., et al. 1992. J. Pharm. Pharmacol. 44, 737.
      Sumner, H., et al. 1992. Biochem. Pharmacol. 43, 2313.
      Product Information
      CAS number20554-84-1
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₅H₂₀O₃
      Chemical formulaC₁₅H₂₀O₃
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetthe expression of COX-2 and proinflammatory cytokines (TNF-α and IL-1) in LPS-stimulated macrophages
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSLY4220000
      Safety Information
      R PhraseR: 20/21/22-40-42/43

      Harmful by inhalation, in contact with skin and if swallowed.
      Limited evidence of a carcinogenic effect.
      May cause sensitization by inhalation and skin contact.
      S PhraseS: 22-36

      Do not breathe dust.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful & Carcinogenic / Teratogenic
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      512732-50MG 04055977272079

      Documentation

      Parthenolide, Tanacetum parthenium - CAS 20554-84-1 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Parthenolide, Tanacetum parthenium - CAS 20554-84-1 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      512732

      Referencias bibliográficas

      Visión general referencias
      Wong, H.R., et al. 1999. Biochem. Biophys. Res. Comm.262, 375.
      Bork, P.M., et al. 1997. FEBS Lett. 402, 85.
      Hwang, D., et al. 1996. Biochem. Biophys. Res. Commun. 226, 810.
      Barsby, R.W., et al. 1992. J. Pharm. Pharmacol. 44, 737.
      Sumner, H., et al. 1992. Biochem. Pharmacol. 43, 2313.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-August-2021 JSW
      DescriptionA sesquiterpene lactone with anti-inflammatory, antisecretory, and spasmolytic properties. Inhibits the expression of COX-2 and proinflammatory cytokines (TNF-α and IL-1) in LPS-stimulated macrophages. Also inhibits NF-κB and activation of MAP kinase.
      FormWhite solid
      CAS number20554-84-1
      RTECSLY4220000
      Chemical formulaC₁₅H₂₀O₃
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (100 mg/ml) or ethanol (20 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful & Carcinogenic / Teratogenic
      ReferencesWong, H.R., et al. 1999. Biochem. Biophys. Res. Comm.262, 375.
      Bork, P.M., et al. 1997. FEBS Lett. 402, 85.
      Hwang, D., et al. 1996. Biochem. Biophys. Res. Commun. 226, 810.
      Barsby, R.W., et al. 1992. J. Pharm. Pharmacol. 44, 737.
      Sumner, H., et al. 1992. Biochem. Pharmacol. 43, 2313.