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14-758M Ret (V804L) Protein, active, 250 µg

Active, N-Terminal GST-tagged, recombinant, human Ret amino acids 658 – end containing the V804L mutation. For use in Kinase Assays.

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14-758M
250 µg  Also available in 10 μg size (cat#14-758) and in bulk (cat# 14-758-K).
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      Descripción

      Replacement Information
      Description
      Catalogue Number14-758M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionRet (V804L) Protein, active, 250 µg
      OverviewN-Terminal GST-tagged, recombinant, human Ret amino acids 658 – end containing the V804L mutation.
      Background InformationThe V804L mutation has been identified in patients with familial medullary thyroid carcinoma (FMTC) (Lombardo F. et al., (2002), JCEM, 87, 1674-1680; Lesueur F. et al, (2005), JCEM, 90, 3454-3457).
      References
      Product Information
      Presentation50mM Tris-HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.
      Quality LevelMQ300
      Applications
      ApplicationActive, N-Terminal GST-tagged, recombinant, human Ret amino acids 658 – end containing the V804L mutation. For use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourceExpressed by baculovirus in Sf21 insect cells.
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Gene Symbol
      • RET
      • CRET
      • CDHF12
      Protein TargetRet
      Purification MethodGlutathione agarose affinity chromatography
      Target Sub-FamilyTK
      UniProt Number
      Molecular Weight79.2 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by phosphorylation of CHKtide.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore -70°C. For maximum recovery of product, centrifuge original vial prior to removing the cap.
      Rapidly thaw the vial under cold water and immediately place on ice. Aliquot unused material into pre-chilled microcentrifuge tubes and immediately snap-freeze the vials in liquid nitrogen prior to re-storage at -70°C.
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-758) and in bulk (cat# 14-758-K).
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      14-758M 04053252478901

      Documentation

      Productos y aplicaciones relacionados

      Alternative Packsize

      Número de referencia Descripción  
      14-758 Ret (V804L) Protein, active, 10 µg Precios y disponibilidad

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      Categorías

      Life Science Research > Proteins and Enzymes > Purified Kinases
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases