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555551 Rho Kinase Inhibitor II - CAS 97627-27-5 - Calbiochem

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: N-(4-Pyridyl)-Nʹ-(2,4,6-trichlorophenyl)urea

Primary Target: ROCK
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      Descripción

      Replacement Information

      Tabla espec. clave

      CAS #Empirical Formula
      97627-27-5C₁₂H₈Cl₃N₃O
      Description
      Overview

      This product has been discontinued.



      A pyridyl urea compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of Rho-associated protein kinase (ROCK; IC50 = 0.2 µM). Displays little activity towards Erk, PKA, PKC, PDGFR, or c-Kit/SCFR (IC50 > 10 µM).
      Catalogue Number555551
      Brand Family Calbiochem®
      SynonymsN-(4-Pyridyl)-Nʹ-(2,4,6-trichlorophenyl)urea
      References
      ReferencesTakami, A., et al. 2004. Bioorg. Med. Chem. 12, 2115.
      Product Information
      CAS number97627-27-5
      ATP CompetitiveY
      FormWhite solid
      Hill FormulaC₁₂H₈Cl₃N₃O
      Chemical formulaC₁₂H₈Cl₃N₃O
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetROCK
      Primary Target IC<sub>50</sub>0.2 µM
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      555551 0

      Documentation

      Rho Kinase Inhibitor II - CAS 97627-27-5 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Rho Kinase Inhibitor II - CAS 97627-27-5 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      555551

      Referencias bibliográficas

      Visión general referencias
      Takami, A., et al. 2004. Bioorg. Med. Chem. 12, 2115.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      SynonymsN-(4-Pyridyl)-Nʹ-(2,4,6-trichlorophenyl)urea
      DescriptionA potent, selective, and ATP-competitive inhibitor of Rho-associated protein kinase (ROCK; IC50 = 200 nM). Does not significantly inhibit the activities of Erk, PKA, PKC, PDGFR, or c-Kit/SCFR (IC50 > 10 µM).
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number97627-27-5
      Chemical formulaC₁₂H₈Cl₃N₃O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesTakami, A., et al. 2004. Bioorg. Med. Chem. 12, 2115.