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23-030 SCF-Fbw7 Protein Complex, Active, 10 µg

Active complex of four (4) full length, recombinant human enzymes: Fbw7, Skp1, Cul1 & Rbx1. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.

SCF-Fbw7 Protein Complex, Active, 10 µg: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Key Applications: Enzyme Assays
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23-030
10 µg  
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      Descripción

      Replacement Information

      Tabla espec. clave

      Key ApplicationsSpeciesCascade Component
      Enzyme AssaysHuman E3
      Description
      Catalogue Number23-030
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionSCF-Fbw7 Protein Complex, Active, 10 µg
      OverviewN-terminal c-Myc, 6His-tagged, recombinant human Smad7 full length, expressed by baculovirus in Sf21 insect cells.
      Alternate Names
      • SCFFbxw7
      • SCFhCdc4
      Background InformationThe SCF (Skp1-Cul1-F-box protein) complexes represent the largest family of ubiquitin-protein ligases and mediate the ubiquitination of a broad spectrum of regulatory and signalling proteins in diverse cellular pathways. The SCF consists of three invariant components, Skp1, Cul1, and Rbx1 and an interchangeable subunit, an F-box protein which is responsible for recruiting specific substrates to be ubiquitinated by the SCF. SCFFbw7 mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell division, growth and differentiation, including Cyclin E1, c-Myc, Notch and c-Jun. Mutations have been found in the Fbw7 subunit of SCFFbw7 in various types of human cancers, therefore Fbw7 is considered to be a potent tumour suppressor.
      References
      Product Information
      Quality LevelMQ100
      Applications
      ApplicationActive complex of four (4) full length, recombinant human enzymes: Fbw7, Skp1, Cul1 & Rbx1. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.
      Key Applications
      • Enzyme Assays
      Biological Information
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Cascade ComponentE3
      Entrez Gene Number
      Purification MethodPurified using glutathione sepharose.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size10 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      23-030 04053252294754

      Documentation

      SCF-Fbw7 Protein Complex, Active, 10 µg Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      SCF-Fbw7 Protein Complex, Active, 10 µg Certificados de análisis

      CargoNúmero de lote
      SCFFbw7 complex, active - D11BP021N-A D11BP021N-A
      SCFFbw7 complex, active - D11BP021ND D11BP021ND
      SCFFbw7 complex, active - D11BP021NF D11BP021NF
      SCFFbw7 complex,active - Dl1BP021NJ DL1BP021NJ

      Licencias necesarias e Información técnica

      Cargo
      Detecting Substrate Ubiquitination by the E3 Ligase, XIAP, Using Quantitative Assays

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      Alternative Packsize

      Número de referencia Descripción  
      23-030M SCF-Fbw7 Protein Complex, Active, 250 µg Precios y disponibilidad

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      Categorías

      Life Science Research > Drug Discovery and Development > Ubiquitin and Proteasome Screening > Ubiquitin E3 Ligases
      Life Science Research > Proteins and Enzymes > Ubiquitin E3 Ligases