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573095 STAT3 Inhibitor Peptide

STAT3 Inhibitor Peptide: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: Ac-PpYLKTK-OH, STAT3 Inhibitor I

Primary Target: STAT3
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical Formula
      C₃₈H₆₃N₈O₁₃P
      Description
      Overview

      This product has been discontinued.



      A Stat3-SH2 domain binding phosphopeptide that acts as a selective inhibitor of Stat3 (signal transducers and activators of transcription 3) signaling with a DB50 of 235 µM (concentration of peptide at which DNA-binding activity is inhibited by 50%). Significantly lowers the DNA-binding activity of Stat3 by forming an inactive Stat3:peptide complex and reduces the levels of active Stat3:Stat3 dimers that can bind DNA. Displays greater affinity for Stat3, and to a lesser extent Stat1, over Stat5.
      Supplied as a trifluoroacetate salt.
      Catalogue Number573095
      Brand Family Calbiochem®
      SynonymsAc-PpYLKTK-OH, STAT3 Inhibitor I
      References
      ReferencesTurkson, J., et al. 2001. J. Biol. Chem. 276, 45443.
      Product Information
      ATP CompetitiveN
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₃₈H₆₃N₈O₁₃P
      Chemical formulaC₃₈H₆₃N₈O₁₃P
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetSTAT3
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceAc-Pro-Tyr(PO₃H₂)-Leu-Lys-Thr-Lys-OH
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      573095 0

      Documentation

      STAT3 Inhibitor Peptide Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      STAT3 Inhibitor Peptide Certificados de análisis

      CargoNúmero de lote
      573095

      Referencias bibliográficas

      Visión general referencias
      Turkson, J., et al. 2001. J. Biol. Chem. 276, 45443.

      Licencias necesarias e Información técnica

      Cargo
      JAK/STAT Signaling Research Focus
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-September-2008 RFH
      SynonymsAc-PpYLKTK-OH, STAT3 Inhibitor I
      DescriptionA Stat3-SH2 domain binding phosphopeptide that acts as a selective inhibitor of Stat3 (signal transducers and activators of transcription 3) signaling with a DB50 of 235 µM (concentration of peptide at which DNA-binding activity is inhibited by 50%). Significantly lowers the DNA-binding activity of Stat3 by forming an inactive Stat3:peptide complex and reduces the level of active Stat3:Stat3 dimer that can bind DNA. Displays greater affinity for Stat3, and to lesser extent Stat1 over Stat5.
      FormWhite lyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₃₈H₆₃N₈O₁₃P
      Peptide SequenceAc-Pro-Tyr(PO₃H₂)-Leu-Lys-Thr-Lys-OH
      Purity≥95% by HPLC
      SolubilityH₂O (1 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesTurkson, J., et al. 2001. J. Biol. Chem. 276, 45443.