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567021 Simvastatin, Sodium Salt - Calbiochem

Simvastatin, Sodium Salt is a carboxylate form of Simvastatin. Active in whole cells and in cell-free preparations. An inhibitor of HMG-CoA reductase.

Simvastatin, Sodium Salt - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: L-Type Calcium Channel Blocker VI

Primary Target: 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase
567021
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Descripción

Replacement Information

Tabla espec. clave

Empirical Formula
C₂₅H₃₉O₆ • Na

Precios y disponibilidad

Número de referencia DisponiblidadEmbalaje Cant./Env. Precio Cantidad
567021-50MG
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      567021-5MG
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      Disponibilidad a confirmar Disponibilidad a confirmar
      Ingrese cantidad 
      Suspendido
      Cantidades limitadas disponibles
      Debe confirmarse disponibilidad
        El resto: se avisará
          El resto: se avisará
          Se avisará
          Póngase en contacto con el Servicio de Atención al Cliente
          Contact Customer Service

          		 Ampolla de plást. 5 mg
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          Description
          OverviewCarboxylate form of Simvastatin (Cat. No. 567020) that is active in whole cells and in cell-free preparations. Also available as a 10 mM solution in H2O (Cat. No. 567022).
          Catalogue Number567021
          Brand Family Calbiochem®
          SynonymsL-Type Calcium Channel Blocker VI
          References
          ReferencesYada, T., et al. 1999. Br. J. Pharmacol. 126, 1205.
          Clutterbuck, R.D., et al. 1998. Br. J. Haematol. 102, 522.
          Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol. 94, 87.
          Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta 1345, 259.
          Vrtovsnik, F., et al. 1997. Kidney Int. 52, 1016.
          Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
          Product Information
          ATP CompetitiveN
          FormBeige solid
          Hill FormulaC₂₅H₃₉O₆ • Na
          Chemical formulaC₂₅H₃₉O₆ • Na
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary Target3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Número de referencia GTIN
          567021-50MG 04055977267112
          567021-5MG 07790788051587

          Documentation

          Simvastatin, Sodium Salt - Calbiochem Certificados de análisis

          CargoNúmero de lote
          567021

          Referencias bibliográficas

          Visión general referencias
          Yada, T., et al. 1999. Br. J. Pharmacol. 126, 1205.
          Clutterbuck, R.D., et al. 1998. Br. J. Haematol. 102, 522.
          Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol. 94, 87.
          Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta 1345, 259.
          Vrtovsnik, F., et al. 1997. Kidney Int. 52, 1016.
          Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-October-2015 JSW
          SynonymsL-Type Calcium Channel Blocker VI
          DescriptionCarboxylate form of Simvastatin (Cat. No. 567020) that is active in whole cells and in cell-free assays. A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. Also inhibits glucose-induced Ca2+-signaling and insulin secretion by blocking L-type Ca2+ channels in rat islet β-cells. Inhibits cell proliferation of human smooth muscle cells. Note: This product is supplied in an active form; no treatment with NaOH in ethanol is required for its activation.
          FormBeige solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₂₅H₃₉O₆ • Na
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (100 mg/ml), Ethanol (25 mg/ml), or H₂O (5 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Standard Handling
          ReferencesYada, T., et al. 1999. Br. J. Pharmacol. 126, 1205.
          Clutterbuck, R.D., et al. 1998. Br. J. Haematol. 102, 522.
          Yokoyama, K., et al. 1998. Mol. Biochem. Parasitol. 94, 87.
          Negre-Aminou, P., et al. 1997. Biochim. Biophys. Acta 1345, 259.
          Vrtovsnik, F., et al. 1997. Kidney Int. 52, 1016.
          Keyomarsi, K., et al. 1991. Cancer Res. 51, 3602.