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608050 TAS-301

A cell-permeable indolinone compound that displays anti-proliferative properties.

TAS-301: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: 3-bis(4-Methoxyphenyl)methylene-2-indolinone

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      Descripción

      Replacement Information

      Tabla espec. clave

      CAS #Empirical Formula
      193620-69-8C₂₃H₁₉NO₃
      Description
      Overview

      This product has been discontinued.





      A cell-permeable indolinone compound that displays anti-proliferative properties. Potently inhibits growth factor-induced VSMCs (vascular smooth muscle cells) migration and proliferation by blocking voltage-independent Ca2+ influx and downstream signals such as Ca2+/PKC-signaling pathway, leading to AP-1 induction and inhibition of cytoskeletal depolymerization. Reported to prevent neointimal thickening following balloon injury to rat carotid and porcine coronary arteries.
      Catalogue Number608050
      Brand Family Calbiochem®
      Synonyms3-bis(4-Methoxyphenyl)methylene-2-indolinone
      References
      ReferencesSasaki, E., et al. 2001. Pharmacology 63, 17.
      Sasaki, E., et al. 2000. J. Pharmacol. Exp. Ther. 295, 1043.
      Sasaki, E., et al. 2000. Jpn. J. Pharmacol. 84, 252.
      Muranaka, Y., et al. 1998. J. Pharmacol. Exp. Ther. 285, 1280.
      Product Information
      CAS number193620-69-8
      FormYellow solid
      Hill FormulaC₂₃H₁₉NO₃
      Chemical formulaC₂₃H₁₉NO₃
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      608050 0

      Documentation

      TAS-301 Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      TAS-301 Certificados de análisis

      CargoNúmero de lote
      608050

      Referencias bibliográficas

      Visión general referencias
      Sasaki, E., et al. 2001. Pharmacology 63, 17.
      Sasaki, E., et al. 2000. J. Pharmacol. Exp. Ther. 295, 1043.
      Sasaki, E., et al. 2000. Jpn. J. Pharmacol. 84, 252.
      Muranaka, Y., et al. 1998. J. Pharmacol. Exp. Ther. 285, 1280.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      Synonyms3-bis(4-Methoxyphenyl)methylene-2-indolinone
      DescriptionA cell-permeable indolinone compound that displays anti-proliferative properties. Potently inhibits growth factor-induced vascular smooth muscle cell (VSMC) migration and proliferation. Reported to block voltage-independent Ca2+ influx and downstream signals such as the Ca2+/PKC-signaling pathway, leading to AP-1 induction and inhibition of cytoskeletal depolymerization. Also reported to prevent neointimal thickening after balloon injury to rat carotid and porcine coronary arteries.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number193620-69-8
      Chemical formulaC₂₃H₁₉NO₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (10 mg/ml) or ethanol
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesSasaki, E., et al. 2001. Pharmacology 63, 17.
      Sasaki, E., et al. 2000. J. Pharmacol. Exp. Ther. 295, 1043.
      Sasaki, E., et al. 2000. Jpn. J. Pharmacol. 84, 252.
      Muranaka, Y., et al. 1998. J. Pharmacol. Exp. Ther. 285, 1280.