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504373 Vicriviroc Malate - CAS 541503-81-5 - Calbiochem

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: (4,6-dimethylpyrimidin-5-yl)(4-((S)-4-((R)-2-methoxy-1-(4-(trifluoromethyl)phenyl)ethyl)-3-methylpiperazin-1-yl)-4-methylpiperidin-1-yl)methanone malate, SCH-D, Vicriviroc, SCH-417690

Primary Target: CCR5
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      Descripción

      Replacement Information

      Tabla espec. clave

      CAS #Empirical Formula
      541503-81-5C₂₈H₃₈F₃N₅O₂·C₄H₆O₅
      Description
      Overview

      This product has been discontinued.



      A potent, noncompetitive allosteric antagonist for CCR5 (IC50 = 0.91 nM). An effective entry inhibitor of HIV-1. Inhibits the initial stages of the virus life cycle. Efects can be resisted by mutation in the gp120 V3 region of HIV-1 both in vitro and in vivo.
      Catalogue Number504373
      Brand Family Calbiochem®
      Synonyms(4,6-dimethylpyrimidin-5-yl)(4-((S)-4-((R)-2-methoxy-1-(4-(trifluoromethyl)phenyl)ethyl)-3-methylpiperazin-1-yl)-4-methylpiperidin-1-yl)methanone malate, SCH-D, Vicriviroc, SCH-417690
      References
      ReferencesBerro, R., et al. 2012. Virology 427, 158.
      Velasco-Velzquez, M, et al. 2012. Cancer Res. 72, 3839.
      Zembruski, N., et al. 2011. J. Antimicrob. Chemother. 66, 802.
      Product Information
      CAS number541503-81-5
      FormBeige powder
      Hill FormulaC₂₈H₃₈F₃N₅O₂·C₄H₆O₅
      Chemical formulaC₂₈H₃₈F₃N₅O₂·C₄H₆O₅
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCCR5
      Primary Target IC<sub>50</sub>0.91 nM
      Purity≥90% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      504373 0

      Documentation

      Vicriviroc Malate - CAS 541503-81-5 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Referencias bibliográficas

      Visión general referencias
      Berro, R., et al. 2012. Virology 427, 158.
      Velasco-Velzquez, M, et al. 2012. Cancer Res. 72, 3839.
      Zembruski, N., et al. 2011. J. Antimicrob. Chemother. 66, 802.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-August-2013 JSW
      Synonyms(4,6-dimethylpyrimidin-5-yl)(4-((S)-4-((R)-2-methoxy-1-(4-(trifluoromethyl)phenyl)ethyl)-3-methylpiperazin-1-yl)-4-methylpiperidin-1-yl)methanone malate, SCH-D, Vicriviroc, SCH-417690
      DescriptionA potent, noncompetitive allosteric antagonist for CCR5 (IC50 = 0.91 nM). An effective entry inhibitor of HIV-1. Inhibits the initial stages of the virus life cycle. Efects can be resisted by mutation in the gp120 V3 region of HIV-1 both in vitro and in vivo.
      FormBeige powder
      CAS number541503-81-5
      Chemical formulaC₂₈H₃₈F₃N₅O₂·C₄H₆O₅
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityDMSO
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBerro, R., et al. 2012. Virology 427, 158.
      Velasco-Velzquez, M, et al. 2012. Cancer Res. 72, 3839.
      Zembruski, N., et al. 2011. J. Antimicrob. Chemother. 66, 802.