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506131 p53 Activator, Cell-Permeable

The p53 Activator, Cell-Permeable modulates the biological activity of p53. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

p53 Activator, Cell-Permeable: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: Fusion Peptide 46

Primary Target: Mutant p53
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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical Formula
      C₁₉₂H₃₁₅N₇₁O₄₉S
      Description
      Overview

      This product has been discontinued.





      A synthetic 22-mer (peptide 46), corresponding to the C-terminal amino acid residues 361 - 382 of p53. This peptide is linked to a sequence from the third helix of the Drosophila Antennapedia homeodomain protein to allow cell-permeability. Binds mutant p53 and restores the growth suppressor functions of p53 protein in human tumor cells. Induces apoptosis in human tumor cell lines carrying mutant or wild-type p53 and has no effect in p53 null tumor cell lines.
      Catalogue Number506131
      Brand Family Calbiochem®
      SynonymsFusion Peptide 46
      References
      ReferencesSelivanova, G., et al. 1999. Mol. Cell Biol. 19, 3395.
      Selivanova, G., et al. 1997. Nat. Med. 3, 632.
      Selivanova, G., et al. 1996. Nucleic Acids Res. 24, 3560.
      Brugidou, J., et al. 1995. Biochem. Biophys. Res. Commun. 214, 685.
      Product Information
      ATP CompetitiveN
      FormLyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₉₂H₃₁₅N₇₁O₄₉S
      Chemical formulaC₁₉₂H₃₁₅N₇₁O₄₉S
      Hygroscopic Hygroscopic
      ReversibleN
      Sold on the basis of peptide contentY
      Applications
      Biological Information
      Primary TargetMutant p53
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide ContentY
      Peptide SequenceH-Gly-Ser-Arg-Ala-His-Ser-Ser-His-Leu-Lys-Ser-Lys-Lys-Gly-Gln-Ser-Thr-Ser-Arg-His-Lys-Lys-Trp-Lys-Met-Arg-Arg-Asn-Gln-Phe-Trp-Val-Lys-Val-Gln-Arg-Gly-OH
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      506131 0

      Documentation

      p53 Activator, Cell-Permeable Certificados de análisis

      CargoNúmero de lote
      506131

      Referencias bibliográficas

      Visión general referencias
      Selivanova, G., et al. 1999. Mol. Cell Biol. 19, 3395.
      Selivanova, G., et al. 1997. Nat. Med. 3, 632.
      Selivanova, G., et al. 1996. Nucleic Acids Res. 24, 3560.
      Brugidou, J., et al. 1995. Biochem. Biophys. Res. Commun. 214, 685.

      Folleto

      Cargo
      Caspases and other Apoptosis Related Tools Brochure
      Interactive Pathway Calendar
      p53 And Related Products
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision08-March-2011 JSW
      SynonymsFusion Peptide 46
      DescriptionA synthetic 22-mer (peptide 46), corresponding to the C-terminal amino acid residues 361-382 of p53. This peptide is linked to a sequence from the third helix of the Drosophila Antennapedia homeodomain protein to allow cell-permeability. Binds mutant p53 and restores the growth suppressor functions of p53 protein in human tumor cells. Induces apoptosis in several human tumor cell lines carrying mutant or wild-type p53 and has no effect in p53 null tumor cell lines.
      FormLyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Chemical formulaC₁₉₂H₃₁₅N₇₁O₄₉S
      Peptide SequenceH-Gly-Ser-Arg-Ala-His-Ser-Ser-His-Leu-Lys-Ser-Lys-Lys-Gly-Gln-Ser-Thr-Ser-Arg-His-Lys-Lys-Trp-Lys-Met-Arg-Arg-Asn-Gln-Phe-Trp-Val-Lys-Val-Gln-Arg-Gly-OH
      Purity≥97% by HPLC
      SolubilityH₂O (1 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesSelivanova, G., et al. 1999. Mol. Cell Biol. 19, 3395.
      Selivanova, G., et al. 1997. Nat. Med. 3, 632.
      Selivanova, G., et al. 1996. Nucleic Acids Res. 24, 3560.
      Brugidou, J., et al. 1995. Biochem. Biophys. Res. Commun. 214, 685.