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  • Certificate of Analysis BI0830 60322

    Tipo de documento:
    Certificado de análisis
    Número de lote:
    60322
    Referencia del producto:
    BI0830
    Nombre del producto:
    Deblocking Reagent 3% Trichloroacetic Acid in Dichloromethane

  • Certificate of Analysis BI0424 60322

    Tipo de documento:
    Certificado de análisis
    Número de lote:
    60322
    Referencia del producto:
    BI0424
    Nombre del producto:
    Oxidizing Reagent, 0.05M, I₂ in Pyridine

  • Certificate of Analysis BI0223 60322

    Tipo de documento:
    Certificado de análisis
    Número de lote:
    60322
    Referencia del producto:
    BI0223
    Nombre del producto:
    Capping Reagent A THF/Acetic Anhydride (9/1)

  • High-performance liquid chromatographic analysis of tamoxifen, toremifene and their major human metabolites. 8376482

    The chromatographic behaviour of tamoxifen, toremifene and their major metabolites was investigated by reversed-phase high-performance liquid chromatography on four stationary phases. Two packings were the usual octadecylsilane type and the other two were octylsilane and octadecylsilane of the type specific for basic compounds. The results provide new insight into variations in selectivity with column type for drugs whose basic properties, owing to the presence of an ionizable nitrogen atom, make their chromatography difficult. The results allow an improvement of the separation of metabolites of tamoxifen and toremifene, two triphenylethylene drugs widely used for the treatment of breast cancer. A method is described for the identification and determination of metabolites formed by incubating the parent drugs with human liver microsomal preparations. The assay has been optimized for the identification and quantification of three major metabolites formed by N-oxidative demethylation of the side-chain, 4-hydroxylation of the aromatic ring and a side-chain deamination followed by hydroxylation. These catalytic activities involve cytochrome P450 enzymes.
    Tipo de documento:
    Referencia
    Referencia del producto:
    12-360
    Nombre del producto:
    Acetyl-Histone H3 (Lys9/14) Peptide

  • Nicotine increases dopamine transporter function in rat striatum through a trafficking-independent mechanism. 17141211

    In previous in vivo voltammetry studies, acute nicotine administration increased striatal dopamine clearance. The current study aimed to determine whether nicotine also increases [(3)H]dopamine uptake across the time course of the previous voltammetry studies and whether dopamine transporter trafficking to the cell surface mediates the nicotine-induced augmentation of dopamine clearance in striatum. Rats were administered nicotine (0.32 mg/kg, s.c.); striatal synaptosomes were obtained 5, 10, 40 or 60 min later. Nicotine increased (25%) the V(max) of [(3)H]dopamine uptake at 10 and 40 min. To determine whether the increase in V(max) was due to an increase in dopamine transporter density, [(3)H]GBR 12935 (1-(2-[bis(4-fluorophenyl)methoxy]ethyl)-4-(3-phenylpropyl)piperazine dihydrochloride) binding was performed using rat striatal membranes; no differences were found between nicotine and saline-control groups at 5, 10 or 40 min post-injection, indicating that nicotine did not increase striatal dopamine transporter density; however, [(3)H]GBR 12935 binding assays determine both cell surface and intracellular dopamine transporter. Changes in cellular dopamine transporter localization in striatum were determined using biotinylation and subfractionation approaches; no differences between nicotine and saline-control groups were observed at 10 and 40 min post-injection. These results suggest that the nicotine-induced increase in dopamine uptake and clearance in striatum may occur via a trafficking-independent mechanism.
    Tipo de documento:
    Referencia
    Referencia del producto:
    LP1
    Nombre del producto:
    VLDL, human