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ABN486 Anti-Anosmin Antibody

Anti-Anosmin Antibody is a highly specific rabbit polyclonal antibody, that targets Anosmin & has been tested in western blotting & ICC.

Anti-Anosmin Antibody : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: KAL1 UniProt Number: P23352
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ABN486
100 µg  
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      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, ICCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABN486
      DescriptionAnti-Anosmin Antibody
      Alternate Names
      • Anosmin
      • Anosmin-1
      • Adhesion molecule-like X-linked
      • Kallmann syndrome protein
      • KALIG-1
      • KAL1
      • HHA
      • KMS
      • ADMLX
      • KAL
      • KALIG1
      Background InformationAnosmin is a large (100 kDa) secreted peripheral membrane heparin binding glycoprotein that plays a role in neurodevelopment. Anosmin influences the patterning of the mitral and tufted cell collaterals and stimulates axon elongation and branching in the olfactory system, and it seems to have a critical role in the spatiotemporal arrangement in cranial neural cell formation. The protein interacts with FGFR1 and promotes FGF receptor mediated gene expression but it also inhibits BMP5 and WNT3A signaling activities. It is thought through this orchestration that Anosmin controls the epithelial–mesenchymal transition and the mesenchymal–epithelial transition during neural crest cell development. Mutations in the Anosmin gene, KAL1, are the cause of hypogonadotropic hypogonadism 1. A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. EMD-Millipore’s anti-Anosmin rabbit polyclonal antibody has been tested in western blot against human MCF7 cells and immunocytochemistry against MCF7 cells in culture.
      References
      Product Information
      FormatAffinity Purified
      Control
      • MCF7cell lysate
      PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Anosmin Antibody is a highly specific rabbit polyclonal antibody, that targets Anosmin & has been tested in western blotting & ICC.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Anosmin in human cerebellum, rat cerebellum, and human thalamus tissues.

      Immunocytochemistry Analysis: 5 µg/mL from a representative lot detected Anosmin in MCF7 cells.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human Anosmin.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • KAL1
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~70 kDa observed. Uncharacterized bands may appear in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in MCF7 cell lysate.

      Western Blotting Analysis: 1µg/mL of this antibody detected Anosmin in 15 µg of MCF7 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      ABN486 04053252923500