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ABT66 Anti-CADM1 Antibody

Detect CADM1 using this Anti-CADM1 Antibody validated for use in WB & IC.

Anti-CADM1 Antibody : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Research Category: Cell Structure Research Sub-Category: Cytoskeleton Gene Symbol: CADM1, IGSF4, IGSF4A, NECL2, SYNCAM, TSLC1 UniProt Number: Q9BY67
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ABT66
100 µg  
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      Tableau de caractéristiques principal

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWB, ICCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABT66
      DescriptionAnti-CADM1 Antibody
      Alternate Names
      • Cell adhesion molecule 1
      • Immunoglobulin superfamily member 4
      • IgSF4
      • Nectin-like protein 2
      • NECL-2
      • Spermatogenic immunoglobulin superfamily
      • SgIgSF
      • Synaptic cell adhesion molecule
      • SynCAM
      • Tumor suppressor in lung cancer 1
      • TSLC-1
      Background InformationCADM1 (also known as cell adhesion molecule 1, Nectin-like protein 2, synaptic cell adhesion molecule. IgSF4 and TSLC-1) is a tumor suppressor part of the immunoglobulin superfamily and has been found to show reduced expression in many different solid tumors. CADM1 has also been found to play a role in the formation of epithelia-like cell structure. Recent research has also linked CADM1 to mediating emotional and social behaviors and motor skills. CADM1 may also be important in psychiatric and behavioral disorders such as autism.
      References
      Product Information
      FormatAffinity Purified
      Control
      • PC3 cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect CADM1 using this Anti-CADM1 Antibody validated for use in WB & IC.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis: A 1:500 dilution from a representative lot detected CADM1 in NIH/3T3, A431, and HeLa cells.
      Biological Information
      ImmunogenLinear peptide corresponding to human CADM1.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CADM1
      • IGSF4
      • IGSF4A
      • NECL2
      • SYNCAM
      • TSLC1
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Mediates homophilic cell-cell adhesion in a Ca2+-independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca2+-independent manner. Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. May contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo. May act as a synaptic cell adhesion molecule that drives synapse assembly. May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.

      SUBUNICT STRUCTURE: Homodimer. Interacts with CRTAM and EPB41L3/DAL1. The interaction with EPB41L3/DAL1 may act to anchor CADM1 to the actin cytoskeleton. Interacts via its C-terminus with the PDZ domain of MPP3 and the PDZ domain of MPP6.

      SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Note: Associates with perinuclear and plasma membranes in vivo. Localized to the basolateral plasma membrane of epithelial cells in gall bladder. Ref.4 UniProtKB Q8R5M8

      DOMAIN: The cytoplasmic domain appears to play a critical role in proapoptosis and tumor suppressor activity in NSCLC. Ref.7 Ref.11

      SEQUENCE SIMILARITIES: Belongs to the nectin family.

      Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

      Contains 1 Ig-like V-type (immunoglobulin-like) domain.
      Molecular Weight~48 kDa & 37 kDa observed.
      Isoform 1 (48 kDa), Isoform 2 (37 kDa).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in PC3 cell lysate.

      Western Blot Analysis: 2 µg/mL of this antibody detected CADM1 in 10 µg of PC3 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      ABT66 04053252420641

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Anti-CADM1 Antibody FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Anti-CADM1 Antibody Certificats d'analyse

      TitreNuméro de lot
      Anti-CADM1 - 2383997 2383997
      Anti-CADM1 - 2048919 2048919
      Anti-CADM1 - 2197298 2197298
      Anti-CADM1 - 2274293 2274293
      Anti-CADM1 - 3192429 3192429
      Anti-CADM1 - 3202279 3202279
      Anti-CADM1 - 3398048 3398048
      Anti-CADM1 - 3729444 3729444
      Anti-CADM1 - NRG1915896 NRG1915896
      Anti-CADM1 -2515428 2515428
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