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AB5699 Anti-Cysteine-rich Motor Neuron 1 Antibody

Anti-Cysteine-rich Motor Neuron 1 Antibody detects level of Cysteine-rich Motor Neuron 1 & has been published & validated for use in IP & WB.

Anti-Cysteine-rich Motor Neuron 1 Antibody : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Research Category: Neuroscience Research Sub-Category: Neurochemistry & Neurotrophins Gene Symbol: CRIM1, CRIM-1, MGC138194, S52 UniProt Number: Q9NZV1
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AB5699
100 µL  
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      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MIP, WBRbSerumPolyclonal Antibody
      Description
      Catalogue NumberAB5699
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Cysteine-rich Motor Neuron 1 Antibody
      Alternate Names
      • CRIM1
      References
      Product Information
      FormatSerum
      PresentationRabbit serum. Liquid.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Cysteine-rich Motor Neuron 1 Antibody detects level of Cysteine-rich Motor Neuron 1 & has been published & validated for use in IP & WB.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Application NotesWestern blot: 1:1,000 using ECL. The antibody reacts with proteins of ~120 kDa. Preferred gel percentage is 7.5%. Suggested blocking buffer is PBS containing 5% non-fat milk. Suggested dilution buffer is PBS containing 1% non-fat milk.

      Immunoprecipitation: 5 μL to 1 mL of cell extract. Preferred tissue/cell lysis buffer is RIPA. Suggested incubation time is 2-4 hours. Suggested capture agent is Protein A.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenRecombinant protein from the cytoplasmic tail of mouse Crim1.
      HostRabbit
      SpecificityCrim1

      SUBCELLULAR LOCALIZATION: Intracellular and Membrane associated.
      Species Reactivity
      • Human
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryMotor neurons are among the earliest neurons to appear after the commencement of cell patterning and the beginning of cell differentiation. Differentiation occurs in a ventral-to-dorsal gradient and is mediated, at least in part, by the concentration of ventrally expressed sonic hedgehog protein (SHH; MIM 600725). Dorsally expressed factors, such as members of the bone morphogenic protein (e.g., BMP4; MIM 112262) and transforming growth factor-beta (e.g., TGFB1; MIM 190180) families, can repress the induction of these neurons. CRIM1 may interact with growth factors implicated in motor neuron differentiation and survival (Kolle et al., 2000 [PubMed 10642437]).[supplied by OMIM]
      Gene Symbol
      • CRIM1
      • CRIM-1
      • MGC138194
      • S52
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9NZV1 # May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface.
      SIZE: 1036 amino acids; 113738 Da
      SUBUNIT: Interacts with BMP4 and BMP7.
      SUBCELLULAR LOCATION: Processed cysteine-rich motor neuron 1 protein: Secreted. & Cell membrane; Single-pass type I membrane protein.
      TISSUE SPECIFICITY: Expressed in pancreas, kidney, skeletal muscle, lung, placenta, brain, heart, spleen, liver and small intestine. Expressed in blood vessels (at protein level).
      PTM: N-glycosylated.
      SIMILARITY: SwissProt: Q9NZV1 ## Contains 4 antistasin-like domains. & Contains 1 IGFBP N-terminal domain. & Contains 6 VWFC domains.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      AB5699 04053252330490