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AB5861 Anti-Melanin Concentrating Hormone Receptor Type 2 Antibody, intracellular, CT

This Anti-Melanin Concentrating Hormone Receptor Type 2 Antibody, intracellular, C-terminus is validated for use in IH for the detection of Melanin Concentrating Hormone Receptor Type 2.

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Research Category: Neuroscience Research Sub-Category: CNS Control of Metabolism, Hormones & Receptors Gene Symbol: MCHR2, MCH-2R, S643b, MCH2, MCHR-2, OTTHUMP00000043201, SLT, GPR145, GPRv17, MCH2R, MCH-R2 UniProt Number: Q969V1
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AB5861
100 µg  
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      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RIHCChAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB5861
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Melanin Concentrating Hormone Receptor Type 2 Antibody, intracellular, CT
      Alternate Names
      • MCH-R2
      Background InformationMelanin Concentrating Hormone Receptor type 2 (MCH-R2) is a G-protein coupled receptor with seven transmembrane domains. MCH-R2 is 340 amino acids in length (approximately 39 kDa) and shares approximately 38% amino acid identity with MCH-R1. Like MCH-R1, it binds MCH with high affinity. However, reports indicate that signaling through this receptor is pertussis insensitive, contrary to MCH-R1. Expression of MCH-R2 mRNA is restricted to several regions of the brain, including the arcuate nucleus and the ventral medial hypothalamous (Sailer, 2001).
      References
      Product Information
      FormatAffinity Purified
      PresentationAffinity purified immunoglobulin in PBS, pH 7.2 containing 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Melanin Concentrating Hormone Receptor Type 2 Antibody, intracellular, C-terminus is validated for use in IH for the detection of Melanin Concentrating Hormone Receptor Type 2.
      Key Applications
      • Immunohistochemistry
      Application NotesImmunohistochemistry: 1 μg/mL on brain cryostat sections. The antibody stains extensively through the brain and is particularly striking in the ganglionic layer of the cerebellum.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenSynthetic 16 amino acid peptide corresponding to the intracellular carboxy-terminus of human MHC-R2.
      Epitopeintracellular, C-terminus
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostChicken
      SpecificityHuman Melanin Concentrating Hormone Receptor Type 2 (MCH-R2). The antibody has been used to stain tissues from rat and mouse as well as human.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • MCHR2
      • MCH-2R
      • S643b
      • MCH2
      • MCHR-2
      • OTTHUMP00000043201
      • SLT
      • GPR145
      • GPRv17
      • MCH2R
      • MCH-R2
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q969V1 # Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis.
      SIZE: 340 amino acids; 38849 Da
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Specifically expressed in the brain, with highest levels in cerebral cortex, hippocampus and amygdala. No expression detected in the cerebellum, thalamus or hypothalamus.
      SIMILARITY: SwissProt: Q969V1 ## Belongs to the G-protein coupled receptor 1 family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain frozen at -20°C in undiluted aliquots for up to 6 months after date of receipt. The antibody can also be diluted 1:1 with glycerol (ACS grade or better) for added stability. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      AB5861 04053252336089