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AB15115 Anti-NARC-1 Antibody

NARC-1 is an antibody targeting the NARC-1 protein, validated for use in WB.

Anti-NARC-1 Antibody : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: PCSK9, NARC1, NARC-1, FH3, HCHOLA3 UniProt Number: Q8NBP7
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AB15115
100 µL  
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      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MWBRbSerumPolyclonal Antibody
      Description
      Catalogue NumberAB15115
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-NARC-1 Antibody
      Alternate Names
      • Neural Apoptosis-Regulated Convertase 1
      • PCSK9
      References
      Product Information
      FormatSerum
      PresentationRabbit serum.
      Quality LevelMQ100
      Applications
      ApplicationNARC-1 is an antibody targeting the NARC-1 protein, validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenSynthetic peptide.
      HostRabbit
      SpecificityNeural apoptosis-regulated convertase 1 [NARC-1, Pcsk9]. By Western blot the antibody recognizes a doublet at ~76 kDa in mouse liver lysate.
      Species Reactivity
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3).
      Gene Symbol
      • PCSK9
      • NARC1
      • NARC-1
      • FH3
      • HCHOLA3
      Purification MethodSerum
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q8NBP7 # May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis.
      COFACTOR: Calcium (Probable).
      SIZE: 692 amino acids; 74372 Da
      SUBUNIT: The precursor protein but not the mature protein may form multimers.
      SUBCELLULAR LOCATION: Secreted.
      TISSUE SPECIFICITY: Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells.
      PTM: The soluble zymogen undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted enzyme.
      DISEASE:SwissProt: Q8NBP7 # Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant.
      SIMILARITY: SwissProt: Q8NBP7 ## Belongs to the peptidase S8 family. & Contains 1 peptidase S8 domain.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20degC in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      AB15115 04053252282270

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      Catégories

      Life Science Research > Antibodies and Assays > Primary Antibodies