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MABF215 Anti-NOD1/CARD4 Antibody, clone 021

Anti-NOD1/CARD4 Antibody, clone 021 is an antibody against NOD1/CARD4 for use in western blotting & flow cytometry.

Anti-NOD1/CARD4 Antibody, clone 021 : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology Gene Symbol: NOD1, CARD4 UniProt Number: Q9Y239
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MABF215
100 µg  
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      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, FCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABF215
      DescriptionAnti-NOD1/CARD4 Antibody, clone 021
      Alternate Names
      • Nucleotide-binding oligomerization domain-containing protein 1
      • Caspase recruitment domain-containing protein 4
      Background InformationNOD1/CARD4, also known as Nucleotide-binding oligomerization domain-containing protein 1, or Caspase recruitment domain-containing protein 4, and encoded by the gene NOD1/CARD4, is an important apoptosis mediating protein that enhances caspase-9-mediated apoptosis. NOD1/CARD4 also mediates cellular responsiveness to intracellular bacterial LPS and forms an intracellular sensing system along with another protein called ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. NOD1/CARD4 is a homodimer that is found in the cytoplasm but also associated with the cell membrane in particular cells such as polarized epithelial cells. NOD1/CARD4 is expressed in many tissues including heart, skeletal muscle, and pancreas. As part of the innate immune system NOD1/CARD4 is part of a family of proteins that are responsible for the initial response of an organism to potentially harmful stressors, pathogens or tissue injury, and accordingly plays an essential role in the pathogenesis of many inflammatory processes, including some cardiovascular diseases.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-NOD1/CARD4 Antibody, clone 021 is an antibody against NOD1/CARD4 for use in western blotting & flow cytometry.
      Key Applications
      • Western Blotting
      • Flow Cytometry
      Application NotesFlow Cytometry Analysis: 2 µg of this antibody from a representative lot detected NOD1/CARD4 in 1X10E6 Jurkat cells. This antibody was produced in collaboration with the Scripps Research Institute.
      Biological Information
      ImmunogenRecombinant protein corresponding to the CARD domain of human NOD1/CARD4.
      EpitopeCARD domain
      Clone021
      Concentration1 mg/mL
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • NOD1
      • CARD4
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~125 kDa observed. The calculated molecular weight of this protein is 108 kDa, but has been observed at ~125 kDa in some cell lysates. An IgG heavy chain may be observed at 55 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluted by Western Blotting in human spleen tissue lysate.

      Western Blotting Analysis: 1 µg/mL of this antibody detected NOD1/CARD4 in 10 µg of human spleen tissue lysate.

      This antibody was produced in collaboration with the Scripps Research Institute. For Scripps Research Institute Validation (Click Here)
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      MABF215 04053252977671