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MABS165 Anti-STAM-binding protein Antibody, clone 4D12.2

This Anti-STAM-binding protein Antibody, clone 4D12.2 is validated for use in Western Blotting and Immunocytochemistry for the detection of STAM-binding protein.

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Research Category: Signaling Research Sub-Category: Ubiquitin & Ubiquitin Metabolism Gene Symbol: AMSH, STAMBP UniProt Number: O95630
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MABS165
100 µg  
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      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, ICCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABS165
      DescriptionAnti-STAM-binding protein Antibody, clone 4D12.2
      Alternate Names
      • STAMBP
      • STAM-binding protein
      • Associated molecule with the SH3 domain of STAM
      • Endosome-associated ubiquitin isopeptidase
      • AMSH
      Background InformationSTAM-binding protein (STAMBP) is a critical metalloprotease in ubiquitin-mediated signaling events that specifically cleaves 'Lys-63'-linked polyubiquitin chains but does not cleave 'Lys-48'-linked polyubiquitin chains. STAM-binding protein is a deubiquitinating (DUB) isopeptidase also known as AMSH, for associated molecule with the SH3 domain of STAM. STAM-binding protein plays a role in cell growth and MYC induction, potentiates BMP signaling and is key in regulating the cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. STAM-binding protein interacts with other key proteins including STAM1, SMAD6/7, SMURF2, and CHMP3. STAM-binding protein is widely expressed and can be found localized to the nucleus, cytoplasm and endosome. Defects in STAM-binding protein result in a congenital syndrome named Microcephaly-capillary malformation syndrome.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ supernatant in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ300
      Applications
      ApplicationThis Anti-STAM-binding protein Antibody, clone 4D12.2 is validated for use in Western Blotting and Immunocytochemistry for the detection of STAM-binding protein.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry analysis: 1:50 dilution from a representative lot detected STAM binding protein in A431 cells
      DyLight™ is a trademark of Thermo Fisher Scientific, Inc. and its subsidiaries.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to Human STAM-binding protein.
      Clone4D12.2
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • AMSH
      • STAMBP
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~50 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by western blotting on Jurkat cell lysate
      Western Blotting Analysis: 1 µg/mL of this antibody detected STAM binding protein in 10 µg of Jurkat cell lysate
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      MABS165 04053252984990