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203895 BTS - CAS 1576-37-0 - Calbiochem

A potent inhibitor of Ca2+-stimulated myosin S1 ATPase (IC₅₀ = ~ 5 µM) and reversibly blocks the gliding motility.

BTS - CAS 1576-37-0 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: N-Benzyl-p-toluenesulphonamide

Primary Target: Ca2+-stimulated myosin S1 ATPase
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203895
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Tableau de caractéristiques principal

CAS #Empirical Formula
1576-37-0C₁₄H₁₅NO₂S

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203895-5MG
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      Description
      OverviewA potent inhibitor of Ca2+-stimulated myosin S1 ATPase (IC50 = ~ 5 µM) and reversibly blocks the gliding motility. It also weakens myosin’s interaction with F-actin. Much less effective in suppressing contraction in rat myocardial or rabbit slow twitch muscle and has no effect on platelet myosin II.
      Catalogue Number203895
      Brand Family Calbiochem®
      SynonymsN-Benzyl-p-toluenesulphonamide
      References
      ReferencesCheung, A., et al. 2002. Nat. Cell Biol. 4, 83.
      Product Information
      CAS number1576-37-0
      ATP CompetitiveN
      FormWhite crystalline solid
      Hill FormulaC₁₄H₁₅NO₂S
      Chemical formulaC₁₄H₁₅NO₂S
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCa2+-stimulated myosin S1 ATPase
      Primary Target IC<sub>50</sub>~5 µM against Ca2+-stimulated myosin S1 ATPase
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSXT5490000
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      203895-5MG 04055977219920

      Documentation

      BTS - CAS 1576-37-0 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      BTS - CAS 1576-37-0 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      203895

      Références bibliographiques

      Aperçu de la référence bibliographique
      Cheung, A., et al. 2002. Nat. Cell Biol. 4, 83.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision22-May-2008 RFH
      SynonymsN-Benzyl-p-toluenesulphonamide
      DescriptionAn aryl sulphonamide that acts as a potent inhibitor of Ca2+-stimulated myosin S1 actin-stimulated ATPase activity (IC50 = ~5 µM). Also blocks actin-stimulated ATPase activity with similar potency (IC50 = 5 µM). Reversibly blocks gliding motility of skeletal muscle myosin (IC50 < 2 µM). Less effective in suppressing contraction in rat myocardial and rabbit slow twitch muscle compared to skeletal muscle. Does not inhibit platelet myosin II.
      FormWhite crystalline solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1576-37-0
      RTECSXT5490000
      Chemical formulaC₁₄H₁₅NO₂S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (200 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesCheung, A., et al. 2002. Nat. Cell Biol. 4, 83.