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505734 BzATP Triethylammonium Salt - CAS 112898-15-4 - Calbiochem

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Synonymes: 2ʹ(3ʹ)-O-(4-Benzoylbenzoyl)adenosine-­5ʹ-triphosphate tri(triethylammonium) salt, P2X7 Purinergic Receptor Agonist, BZATP, 2 ,3 -O-(4-benzoylbenzoyl)ATP, P2X Purinergic Receptor Agonist, BZATP

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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      112898-15-4C₂₄H₂₄N₅O₁₅P₃•3C₆H₁₅N
      Description
      OverviewA prototypic P2X7 purinergic receptor agonist that exhibits about 3-fold higher agonistic potency for induction of nucleotide channels than ATP (EC50 = 15 µM vs 50 µM). Serves as a photo-affinity analog of ATP. Its agonistic activity is significantly reduced in the presence of serum albumin. Can serve as a substrate analog for submitochondrial particle ATPase activity (Km = 940 µM). Induces a dose-dependent decrease in wild-type murine neural progenitor cell viability and an increase in caspase-3 activity. These effects are not observed in P2X7-/- mice.
      Catalogue Number505734
      Brand Family Calbiochem®
      Synonyms2ʹ(3ʹ)-O-(4-Benzoylbenzoyl)adenosine-­5ʹ-triphosphate tri(triethylammonium) salt, P2X7 Purinergic Receptor Agonist, BZATP, 2 ,3 -O-(4-benzoylbenzoyl)ATP, P2X Purinergic Receptor Agonist, BZATP
      References
      ReferencesMessemer, N., et al. 2013. Neuropharmacology. 73, 122.
      Michel, A.D., et al. 2001. Br. J. Pharmacol. 132, 1501.
      Erb, L., et al. 1990. J. Biol. Chem. 265, 7424.
      William, N., and Coleman, P.S. 1982. J. Biol. Chem. 257, 2834.
      Product Information
      CAS number112898-15-4
      FormWhite solid
      Hill FormulaC₂₄H₂₄N₅O₁₅P₃•3C₆H₁₅N
      Chemical formulaC₂₄H₂₄N₅O₁₅P₃•3C₆H₁₅N
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      505734 0

      Documentation

      BzATP Triethylammonium Salt - CAS 112898-15-4 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Références bibliographiques

      Aperçu de la référence bibliographique
      Messemer, N., et al. 2013. Neuropharmacology. 73, 122.
      Michel, A.D., et al. 2001. Br. J. Pharmacol. 132, 1501.
      Erb, L., et al. 1990. J. Biol. Chem. 265, 7424.
      William, N., and Coleman, P.S. 1982. J. Biol. Chem. 257, 2834.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-August-2013 JSW
      Synonyms2ʹ(3ʹ)-O-(4-Benzoylbenzoyl)adenosine-­5ʹ-triphosphate tri(triethylammonium) salt, P2X7 Purinergic Receptor Agonist, BZATP, 2 ,3 -O-(4-benzoylbenzoyl)ATP, P2X Purinergic Receptor Agonist, BZATP
      DescriptionA prototypic P2X7 purinergic receptor agonist that exhibits about 3-fold higher agonistic potency for induction of nucleotide channels than ATP (EC50 = 15 µM vs 50 µM). Serves as a photo-affinity analog of ATP. Its agonistic activity is significantly reduced in the presence of serum albumin. Can serve as a substrate analog for submitochondrial particle ATPase activity (Km = 940 µM). Induces a dose-dependent decrease in wild-type murine neural progenitor cell viability and an increase in caspase-3 activity. These effects are not observed in P2X7-/- mice.
      FormWhite solid
      CAS number112898-15-4
      Chemical formulaC₂₄H₂₄N₅O₁₅P₃•3C₆H₁₅N
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O (100 mM)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesMessemer, N., et al. 2013. Neuropharmacology. 73, 122.
      Michel, A.D., et al. 2001. Br. J. Pharmacol. 132, 1501.
      Erb, L., et al. 1990. J. Biol. Chem. 265, 7424.
      William, N., and Coleman, P.S. 1982. J. Biol. Chem. 257, 2834.